Spinal cord injury is extremely debilitating, both at physiological and psychological levels, changing completely the patient's lifestyle. The introduction of biomaterials has opened a new window to develop a therapeutic approach to induce regeneration after injury due to similarities with extracellular matrix. Particularly, hydrogels have the ability to support axonal growth and endogenous regeneration. Moreover, they can also act as potential matrixes in which to load and deliver therapeutic agents at injury site. In this review, we highlight some important characteristics to be considered when designing hydrogels as delivery systems (DS), such as rheology, mesh size, swelling, degradation, gelation temperature and surface charge. Additionally, affinity-based release systems, incorporation of nanoparticles, or ion-mediated interactions are also pondered. Overall, hydrogel DS aim to promote a sustained, controlled and prolonged release at injury site, allowing a targeted oriented action of the therapeutic agent that will be used.

The dielectric constant, dielectric loss and saturation magnetization of the polymer composite films increase with increasing CoFe2O4 (CFO) content, being 13, 0.13 and 13 emu.g-1 respectively, for x=20. The magnetodielectric (MD) coupling also depend on the CFO content, the change in the dielectric response (MDE(%)) being the highest for the x=20 sample (4.2%). On the other hand, the highest value of the MD coefficient (γ) is higher on the x=3 sample (0.015 emu-2 g 2). Those values are favourably compared with the ones found in the ceramicbased MD materials, being the highest reported for polymer composites. 2 These facts, together with the flexibility and scalable production of the composites, leads to their large application potential in areas such as filters, magnetic field sensors and actuators, among others.

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