The present study was carried out during two consecutive Kharif, seasons of 2020 & 2021 at Instructional Farm, Rajasthan College of Agriculture, Maharana Pratap University of Agriculture & Technology, Udaipur, Rajasthan to assess the response of maize crop under foliar application of zinc based nanofertilizer and varying fertility levels on quality, yield and economics in Southern Rajasthan. The experiment was laid out in a factorial randomized design with three replications comprising four foliar application of nanofertilizer (Control, at knee high stage, at 50% tasseling stage and both at knee high stage and at 50% tasseling stage) and four fertility levels (100% RDF, 90% RDF, 80% RDF and control). Significantly highest protein content of maize (11.13 % and 10.97 %) was found in with dual foliar application of nanofertilizer and 90 per cent RDF, respectively. The significantly highest net return and B:C ratio were found under dual foliar application of nanofertilizer 82956 and 3.04) and soil application of 90 per cent RDF (Rs. 86112 and 3.15) in tested maize crop.