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Purine nucleotide liberation and their metabolic rate of interconversion may be important in the development of hypertension and its renal consequences. In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric acid concentration and xanthine dehydrogenase/xanthine oxidase (XDH/XO) in patients with essential hypertension, patients with chronic renal diseases on dialysis, and control individuals. The pattern of nucleotide catabolism was significantly shifted toward catabolic compounds, including ADP, AMP, and uric acid in patients on dialysis program. A significant fall of ATP was more expressed in a group of patients on dialysis program, compared with the control value (p<0.001), while ADP and AMP were significantly increased in both groups of patients compared with control healthy individuals (p<0.001), together with their final degradation product, uric acid (p<0.001). The index of ATP/ADP and ATP/uric acid showed gradual significant fall in both the groups, compared with the control value (p<0.001), near five times in a group on dialysis. Total XOD was up-regulated significantly in a group with essential hypertension, more than in a group on dialysis. The activity of XO, which dominantly contributes reactive oxygen species (ROS) production, significantly increased in dialysis group, more than in a group with essential hypertension. In conclusion, the examination of the role of circulating purine nucleotides and uric acid in pathogenesis of hypertension and possible development of renal disease, together with XO role in ROS production, may help in modulating their liberation and ROS production in slowing progression from hypertension to renal failure.

VO2max was significantly lower in the iron deficient anemic group versus the latent iron deficient group. Iron supplementation during a two-month training period significantly improved body iron status in the iron deficient female athletes with or without anemia, and significantly increased VO2max only in the subjects with iron deficiency anemia.

This paper presents the results of parameter identification of static load characteristics on the basis of large number of field tests. The parameters of most frequently used, polynomial and exponential load model are determined using two different ways of normalization -normalization with voltage and power values just before the voltage change, and normalization with rated voltage and power values. Significant differences between corresponding identified parameter values and predicted power values are found depending on the way of normalization. Better characteristics of normalization with rated voltage and power values are emphasized. This normalization is suggested for power system analyses because another way of normalization causes large parameter deviations and big mistakes in prediction of load values in the examined voltage range, from 0.95 to 1.1p.u. . Currently she is a Research and Teaching Assistant at the same university. Her research interest include electrical power system analysis, load modeling and power quality. Dobrivoje P. Stojanović (M'96) received Dipl.Ing. and Ph.D. degrees from the Faculty of Electrical Engineering, University of Priština, Priština, in 1971 and 1985, respectively, and the M.S. degree from the