Berries of Vaccinium species have been a source of food and pharmaceutical ingredients. The ethanol, methanol and chloroform extracts of Vaccinium leschenaultia was investigated for anti-inflammatory activity. All the extracts (150 and 300mg/kg each) were found to significantly (P<0.05) inhibit paw edema induced by carrageenan in rats. The results indicated that the methanol extract with the dose of 300mgkg-1 b.w. and the chloroform extract with the dose of 300mgkg-1 b.wt. showed maximum anti-inflammatory activity as compared to the reference drug, Indomethacin. V. leschenaultia could be used as a potential source of antiinflammatory agent.