The authors present complex analysis of US–Russia relations under the Biden Administration. W. Mead’s methodology (typology of foreign policy ideology) and S. Gunnitsky and A. Tsygankov’s theoretical framework (Wilsonian approach) are used. The article examines the motives of Russian and American foreign policies towards each other, as well as the outcomes for the Russia factor in US domestic politics and its impact on the bilateral relations. The authors identify the nature of ideological and political confrontation of the two nations which stems from their mutual perceptions and interpretations of the world order. It is revealed that the strengthening of ideological motivation of US foreign policy under the Biden Administration is aimed to rally Western countries behind the rivalry with illiberal regimes (Russia and China). At the same time, Russia perceives the current confrontation with the United States as an existential threat since it challenges its geopolitical power and national identity. The research looks into such aspects of US–Russia relations as sanctions against Russia, climate change interaction, global security and arms control. The authors conclude that US–Russia ideological confrontation is systematic; steps towards cooperation are aimed at preventing possible escalation. In the near future, US–Russia relations can be considered as a combination (i.e. sanctions, supporting Russian opposition, countering Russia in the post-Soviet region) and selective dialogue and cooperation on such issues as strategic stability, arms control, cybersecurity and climate change. US–Russia relations are not likely to undergo fundamental changes until at least 2024, when new electoral cycles start both in Russia and in the United States. Under current conditions, the management of the US–Russia confrontation remains the major goal for the sides.