changes of annular ligament at stenosing ligamentitis of the fingers of the hand. National Medical University named after O.O. Bohomoltsia, Donetsk National Medical University named after M. Gorky, State Enterprise "Institute of Traumatology and Orthopedics" of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine. ABSTRACT. Background. According to the data of the world literature among the diseases of the tendon-ligament apparatus of the hand, the processes of stenosis of the fibrous channels amount to 43.8%, and the stenosing ligamentitis of the fingers of the hand-up to 22.3% of cases. The pathogenesis of the disease is not fully established. Objective. To complete knowledge of the pathogenesis of stenosingligamentitis of the fingers of the hand through histological and morphometric studies. The study material was biopsy specimens of the altered ring-shaped ligament in 57 adult patients received during surgery. For a comparative assessment of morphological changes, 11 ring-shaped ligaments in corpses without a common pathology and local manifestations of the hand were examined. Results. In untreated patients (group I), with an increase in the duration of the disease, signs of lymphocyte-cell infiltration, edema of the ring-shaped ligament and distroficdegenerative changes accompanied by a decrease in the fibrillar component and the appearance of chondrogenic foci increased. In patients of the second group, the pathological process was characterized by the lymphocyte-fibroblastic phase of independence from the duration of the disease. At the same time, changes in the cellular composition of fibrous connective tissue prevailed. Conclusion. In patients of group I, an increase in the specific area of the main amorphous substance was determined 7.92 times and 2.57 times the macrophage-lymphocytic infiltrates of endothendinia and perithendinium, and in endothendia they were accompanied by collagenolysis and foci of ectopic chondrogenesis. In patients of group II, the proportion of the area of endothendia increased by 42.46% due to early violations of the architecture of the ligament fibers and lymphocytic infiltration; in the epithendia, the hypercellular regions were determined with dense hyperchromicfibrocytes. After 12 months The specific area of the endothendia increased by 4.76 times.

Background. Chronically progressive course of psoriatic arthritis, not the certainty of pathogenetic units, and accordingly errors in diagnosis and treatment lead to significant negative results and disability of patients. Objective is to improve the results of the diagnosis of PA by examining the morphological features of the disease. Methods. Histomorphological studies performed on tissues removed during surgery on the joints in 32 patients. The material distributed into groups depending on the severity of the clinical manifestations of the disease. Results. At the beginning of the disease and at the exudative-proliferative stage, a pattern of pronounced inflammatory process, mainly exudative, serous-fibrinous character, was noted in the capsule of the joint. The most significant changes occurred in the synovial membrane, where marked proliferation of the integumentary synovial cells, hypertrophy and hyperplasia of the synovial membrane were observed with the formation of a large number of villi and folds. At histological examination in the tissues of the joint with a dystrophicdegenerative stage there was a pronounced exudative-proliferative inflammatory process, with significant degenerativedystrophic and fibro-sclerotic changes. Conclusion. Histological studies in patients with PA, evidence of the presence of a sharp non-specific, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, syllabic history changes. Pathological changes in the articular cartilage and subordinate epiphysis bone are manifested by significant degenerative-dystrophic and destructive manifestations.