No abstract

In a study of 115 patients, the effect of the interference of IPL exposure using filters of 640 nm and 560 nm and the use of an erbium fractional laser with a wavelength of 1565 nm on microcirculation in patients with involutive skin changes was studied. The basis of all reparative processes is the microcirculatory link, as a unit of the trophic system of the skin. Studying the effect of phototechnologies and laser fractional exposure on microcirculation, based on the results of these studies, it is possible to develop algorithms for patient management, including additional treatment methods, as well as an algorithm for standardizing procedures, including the multiplicity and number of procedures. These studies can be the starting point for the introduction of standards that will reduce the number of complications, as well as increase the clinical effectiveness of the treatment, which will make the method more widely available. The assessment of the state of microcirculation was carried out using the method of laser Doppler flowmetry (LDF), using the mathematical analysis of the wavelet transform. Under the influence of the interference of IPL exposure using filters of 640 nm and 560 nm and the use of an erbium fractional laser with a wavelength of 1565 nm, a positive dynamics of the parameters of all parts of the microcirculation was revealed according to the LDF data. In women with spastic type of MC, the initially increased neurogenic and myogenic tone of the arterioles decreased, and endothelial function improved. In women with hyperemic type of MC, there was an improvement in neurogenic tone, correction of endothelial dysfunction, and elimination of congestion in the venular link of MC. However, the above changes were more noticeable in patients with hyperemic type of MC.

A clinical observation of the dermal integration of low-concentration products based on hyaluronic acid produced by KPM and IPN-Like technologies is presented. KPM technology is a method of obtaining a cohesive poly-compacted gel matrix of hyaluronic acid, which determines the peculiarity of distribution in the skin due to particles of different densities in one product. On the one hand, the drug remains at the injection site after injection due to dense particles, on the other hand, translocation of loose particles into a more modifed part of the dermis. The clinical effect is manifested in the form of full integration of the drug into the dermis, imitating natural volumes. IPN-Like technology involves the preparation of a hyaluronic acid preparation from two monophase chains with low and high elasticity. Interpenetrating stabilized chains are obtained under pressure. Partial independence of IPN structures is necessary for the predicted integration and distribution of the drug in tissues, whereas the increased density of cross-linking nodes strengthens the intensity of the chemical bond, strengthens the fxation of the drug at the injection site. The study was conducted on seven patients using ultrasound scanning before the procedure, during the procedure to control the introduction into the required layer, 15 minutes after the procedure and 2 months later. To objectify the data, skin proflometry was used and photodocumentation in the designated time frame. In the presented clinical case, when comparing the distribution of fllers based on hyaluronic acid, it was revealed that all drugs are well distributed in the surface layers of the dermis, which makes it possible to safely inject drugs created using IPN-Like technology in the same techniques and to the same depth as the drug with CPM technology. According to ultrasound of the skin, drugs produced by IPN-Like technology showed greater effectiveness in terms of dermis thickness after 2 months.

No abstract

No abstract