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To solve many modern biological and biotechnological tasks it is necessary to realize strictly control and regulation of temperature of the cells and their organelles. This tasks include control of various exo-and endothermic reactions, monitoring of tissues' and individual cell's temperature in in vitro researches and in vivo procedures such as the hyperthermia procedure that used for cancer treatment. The today known methods of measuring and controlling of temperature at the cellular level can not provide the necessary level of locality and accuracy due to too big size and heightened sensitivity to external factors. The real alternative of existing today methods is nanoscale temperature biosensor operating on a ratiometric principle and based on the composite structure from polymers and colloidal quantum dots. In this paper we present a working model and plan of investigation of ratiometric nanoscale polymer nanobiothermometer based on quantum dots.

One of the most actual tasks in biotechnology is the creation of a new generation of nanobiosensors with improved brightness, photo stability, and sensitivity.