This article gives historical overview of the development of international and European dermatovenereological societies. The first European Dermatological Society and the first world Venereological Society open in Russia. Taking into consideration the fact that it was the first officially registered national dermatological society whereas Municipal Society of New York and American National Society were not registered by state authorities, the Russian Society is regarded here as the first world official dermatological society. This article reviews the proffesional development of Prof Benjamin Mikhialovitch Tarnowsky (1837-1906) the most significant dermatovenerologist, influenced the development of world and Russian dermatovenerology, worked in the first world hospital specifically devoted to venereology, Kalinkinskaya Hospital ( founded in 1750, Saint Petersburg). Depicts XII International Congress, held in Moscow in August 7-14th, 1897, where the dermotology section was represented by internationally recognized scientists. Among speakers Kaposi (Wien), Hallopeau (Paris), Gaucher (Paris), Barthelemy(Paris), Wolf (Strassburg), Rosenthal (Berlin), Nikolsky (Kiev), Lindstrem (Kiev), Jullien (Paris), Poper- Mor (Budapest), Schwimmer (Budapest), Pospelov (Moscow), Tarnowsky( Saint Petersburg); such sientists as Unna, Campana, Lassar, Soffiantini, van Hoorn, Vatrashevsky, Yakovlev, Sack participated in the discussion.

Cell differentiation affections substantiate the urgency of the problem related to studying mutual impact of primary or secondary endocrine pathology and hyperproliferative skin diseases. Psoriasis is one of the most demonstrative pathologies for this study for being a prevalent and genetically predetermined disease with a chronic and relapsing course characterized by increased proliferation of keratinocytes, abnormal differentiation process of epidermis cells, inflammatory and immune changes in derma, and dyshormonal disorders are among factors triggering the disease. The study involved 61 male patients. The study group (n = 43) comprised patients with circumscribed psoriasis vulgaris at the progression stage while the control group (n = 18) comprised healthy people. Blood concentration of such hormones as prolactin and cortisone was assessed by the immune-enzyme assay method. An increased cortisone concentration in patients suffering from psoriasis vs. control group was revealed. Psoriatic patients tend to have an increased prolactin level.

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The article is dedicated to the clinical and social analysis of problems concerning patient's and parent's compliance as well as investigation of the impact of various factors to treatment compliance in pediatric dermatology settings. For this purpose specially designed questionnaires for the participants of development of the treatment compliant behavior were used: physicians, pediatric patients of 13 to 18 years old suffering of chronic dermatoses, and their parents. There are the following main predictors of low compliance among dermatological pediatric population: psychological problems of patients; an attitude of a patient and his/her family to the treatment of the disease; lack of confidence among patient in the provided therapy (only 20.2% of adolescents and 56.4% of their parents always accurately follow the prescribed treatment); incomplete awareness of patients and their parents regarding the disease (30.9% of parents noted that by their opinion they are adequately informed concerning the disease of their child); duration of therapy, which could be not always effective or legitimating expectations of patients; inter-individual relationship impairment within the triad of practitioner-child-parents. Taking into account the circumstances, professional and personal qualities of the attendant physician, the adherence by him/her the principles of medical ethics are of primary importance for better treatment compliance.

Erythroderma is the term used for naming any inflammatory skin disease affecting over 90% of cutaneous surface. Numerous etiologic factors may background erythroderma; however, this condition is most often associated with such underlying diseases as eczema, drug hypersensitivity syndrome, cutaneous epidermotropic lymphoma, photosensitization. Being the most severe clinical form of psoriasis, psoriatic erythroderma may be a life hazard in patients with psoriasis, requiring admission and systemic treatment. The paper reviews modern data on psoriasis and psoriatic erythroderma pathogenesis. The biological role of IL-36γ/IL-1F9 - novel specific marker of psoriasis - is described in detail. Data of researches of this marker in different forms of inflammatory skin disease are discussed. Unlike other earlier described markers of psoriasis, for example, S100 A7, A8, A9 proteins, IL-36γ was highly specific to psoriasis, and rarely found at other inflammatory skin diseases (atopic dermatitis, contact dermatitis). The role of IL-36γ in diagnosing erythroderma in patients with psoriasis is described. The most specific and promising marker for distinguishing psoriatic erythroderma from other forms of erythroderma, IL-36γ can be detected at early stages of the disease, allowing to administer early causative treatment, improving treatment effect and preventing complications.