Purpose Psychosocial stress is associated with obesity in some populations, but it is unclear whether the association is related to migration. This study explored associations between psychosocial stress and obesity among Ghanaian migrants in Europe and non-migrant Ghanaians in Ghana. Methods Cross-sectional data from the RODAM study were used, including 5898 Ghanaians residing in Germany, the UK, the Netherlands, rural Ghana, and urban Ghana. Perceived discrimination, negative life events and stress at work or at home were examined in relation to body mass index (BMI) and waist circumference (WC). Linear regression analyses were performed separately for migrants and non-migrants stratified by sex. Results Perceived discrimination was not associated with BMI and WC in both migrants and non-migrants. However, negative life events were positively associated with BMI (β = 0.78, 95% CI 0.34-1.22) and WC (β = 1.96, 95% CI 0.79-3.12) among male Ghanaian migrants. Similarly, stress at work or at home was positively associated with BMI (β = 0.28, 95% CI 0.00-0.56) and WC (β = 0.84, 95% CI 0.05-1.63) among male Ghanaian migrants. Among non-migrant Ghanaians, in contrast, stress at work or at home was inversely associated with BMI and WC in both males (β = − 0.66, 95% CI − 1.03 to − 0.28; β = − 1.71 95% CI − 2.69 to − 0.73, respectively) and females (β = − 0.81, 95% CI − 1.20 to − 0.42; β = − 1.46, 95% CI − 2.30 to − 0.61, respectively). Conclusions Negative life events and stress at work or at home are associated with increased body weight among male Ghanaians in European settings, whereas stress at work or at home is associated with reduced body weight among Ghanaians in Ghana. More work is needed to understand the underlying factors driving these differential associations to assist prevention efforts.

Background Psychosocial stress is associated with obesity in some populations, but it is unclear whether the association is related to migration. Aim This study explored associations between psychosocial stress and obesity among Ghanaian migrants in Europe and non-migrant Ghanaians in Ghana. Methods Cross-sectional data from the RODAM study were used, including 5898 Ghanaians residing in Germany, the UK, the Netherlands, rural Ghana, and urban Ghana. Perceived discrimination, negative life events and stress at work or at home were examined in relation to body mass index (BMI) and waist circumference (WC). Linear regression analyses were performed separately for migrants and non-migrants stratified by sex. Results Perceived discrimination was not associated with BMI and WC in both migrants and non-migrants. However, negative life events were positively associated with BMI (β = 0.78, 95% CI, 0.34 to 1.22) and WC (β = 1.96, 95% CI, 0.79 to 3.12) among male Ghanaian migrants. Among non-migrant Ghanaians, in contrast, stress at work or at home was inversely associated with BMI and WC in both males (β=-0.66, 95% CI, -1.03 to -0.28; β=-1.71 95% CI, -2.69 to -0.73, respectively) and females (β=-0.81, 95% CI, -1.20 to -0.42; β=-1.46, 95% CI, -2.30 to -0.61, respectively). Conclusions Negative life events are associated with increased body weight among Ghanaians in European settings, whereas stress at work or at home is associated with reduced body weight among Ghanaians in Ghana. More work is needed to understand the underlying factors driving these differential associations in order to assist prevention efforts. Key messages Negative life events are associated with increased body weight among Ghanaians in European settings, whereas stress at work or at home is associated with reduced body weight among Ghanaians in Ghana. More work is needed to understand the underlying factors driving these differential associations in order to assist prevention efforts.

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We conducted a study to examine the effect of body fat distribution on the physiological response to a dietary fat intervention with medium chain fatty acids (MCFA) vs long‐chain fatty acids (PUFA) in humans. The physiological response was evaluated as fatty acid kinetics (plasma and subcutaneous fat appearance), plasma lipoprotein profiles and clinical chemistry parameters. In a cross‐over trial, 12 male subjects (age 51±7 y; BMI 28.5±0.8 kg.m‐2), divided in 2 groups according to waist‐hip ratio, were supplemented 60 grams/day MCFA (C8:0, C12:0) or PUFA (C18:2n‐6) for three weeks, with a wash‐out period between supplementation periods of six weeks. Fatty acid metabolism kinetics were studied by supplying [1,2,3,4‐13C4]C8:0 and [U‐13C18]C18:2n‐6 tracers together with a meal on the test day at the end of each intervention period. Samples taken at different time points after tracer administration were analyzed by GC‐C‐IRMS for concentration‐ and isotopic analysis. A clear treatment effect on fat metabolism was concluded from lipoprotein profiles as well as subcutaneous fat composition data from adipose tissue biopts. From the stable isotope data we conclude the presence of differences in acute fatty acid uptake influenced by treatment and fat disposition, that are moreover different in upper body obese vs lower body obese.