Several mixed oxide catalysts were prepared by coprecipitation for dimethyl carbonate (DMC) synthesis from methyl carbamate and methanol. During the batch process, the DMC yield was below 35 %. In order to minimize the unfavorable thermodynamic equilibrium and side reactions for the DMC synthesis, a fixed‐bed reactor was designed. A maximum DMC yield of ∼ 73 % could be realized over a ZnO‐Al2O3 catalyst. The effects of reaction conditions for this type of reactor were investigated in detail.