The effect of allogenic combined transplantation of placental multipotent mesenchymal stromal and hemopoietic stem cells on regeneration of the myeloid tissue and spleen after acute blood loss was studied in laboratory mice. Combined transplantation of these cells did not change the content of cytogenetically modified cells in the bone marrow under normal conditions, but reduced their levels after acute blood loss. Combined transplantation of multipotent mesenchymal stromal and hemopoietic stem cells promoted activation of erythropoiesis and granulocytopoiesis. The major morphometric and cytological parameters of the white pulp of the spleen decreased, presumably due to immunosuppressive effect of multipotent mesenchymal stromal cells.

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The biochemical properties due to which cerium oxide nanoparticles are able to perform the functions of certain enzymes — oxidoreductases, phosphatases, etc., are actively being investigated. The low toxicity of cerium dioxide nanoparticles ensures the comparative safety of its use for medical purposes, which makes it possible to consider this material as a potential drug for the treatment of a number of diseases, primarily associated with oxidative stress. The number of experimental papers published annually on the study of cerium dioxide nanoparticles has increased more than 100 times over the past 20 years, which indicates an increasing interest in this issue. However, many properties inherent in cerium dioxide nanoparticles still remain insufficiently investigated. The aim of the study was to generalize and analyze the data presented in the PubMed, E-Library, Google Scholar databases on cerium oxide nanoparticles as scavengers of reactive oxygen species (ROS) and active nitrogen forms with multi-enzyme mimetic activity, including catalase (Cat), superoxide dismutase (MnSOD₂) and peroxidase activity. These effects of cerium oxide nanoparticles are primarily aimed at modifying oxidative stress, which can significantly improve the treatment of many diseases in the development of which oxidative stress occurs. Taking into account the global burden of liver diseases, this review analyzes experimental studies on the therapeutic effect of cerium oxide nanoparticles on acute and chronic liver diseases.

Aim. Study of the hormonal status and the level of pro-inflammatory cytokines in the blood plasma in experimental hypothyroidism and the effect of the organoiodine complex with rebaudioside A. Materials and methods. Endemic thyroid dysfunction was modeled in sexually mature male white rats by daily intragastric administration of thiamazole for 21 days at a dose of 25 mg / kg. In the blood serum, the content of thyrotropin, total and free thyroxine, total triiodothyronine, testosterone, luteinizing, follicle-stimulating and parathyroid hormones, corticosterone, interleukins-1-beta and -6, tumor necrosis factor-alpha was studied. The animals were divided into four groups of 10 each: control, experimental, comparison and main. Results. The development of hypothyroidism was characterized by an increase in the content of thyroid-stimulating, luteinizing, follicle-stimulating and parathyroid hormones, as well as pro-inflammatory cytokines. At the same time, testosterone levels decreased, while corticosterone levels were within physiological fluctuations. Conclusion. The use within 30 days of the recovery period after the development of hypothyroidism of the iodosaccharide complex based on steviol glycoside rebaudioside A used in the food industry daily at a dose of 25 mg / kg of rat weight led to the normalization of the content of the studied hormones and cytokines in the blood plasma, characterizing the effectiveness of the new organoiodine product.

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