ObjectivesTo assess the skeletal and dental maxillary transverse compensation (yaw) on the cone beam computed tomography (CBCT) three‐dimensional reconstructed image of the skull in two groups of patients, both clinically affected by a class III malocclusion with deviation of the lower midline.Materials and MethodsAn observational retrospective study was designed to analyse differences in two groups of patients, the first one was composed by patients affected by horizontal condylar hyperplasia, the second one by patients affected by dento‐skeletal asymmetric class III malocclusion. Each group was composed by 15 patients. Transverse analysis was performed by measuring five landmarks (three bilateral and two uneven) with respect to a mid‐sagittal plane; sagittal analysis was performed by measuring the sagittal distance on the mid‐sagittal plane between bilateral points. Means were compared through inferential analysis.ResultsIn the condylar hyperplasia group, all differences between the two sides were not statistically significant, nor for canines' difference (P = .0817), for molars (P = .1105) or for jugular points (.05871). In the class III group, the differences between the two sides were statistically significant for molars (P = .0019) and jugular points (P = .0031) but not for canines (P = .1158). Comparing the two groups, significant differences were found only for incisors' midline deviation (P = .0343) and canine (P = .0177).ConclusionThe study of the yaw on CBCT should be integrated into three‐dimensional cephalometry and could help in differentiating the various malocclusion patterns.