The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with the EuPathDB projects. As a Bioinformatics Resource Center funded by the National Institutes of Health, with additional support from the Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists and fungi) and relevant free-living or non-pathogenic species or hosts. Designed to empower researchers with access to Omics data and bioinformatic analyses, VEuPathDB projects integrate >1700 pre-analysed datasets (and associated metadata) with advanced search capabilities, visualizations, and analysis tools in a graphic interface. Diverse data types are analysed with standardized workflows including an in-house OrthoMCL algorithm for predicting orthology. Comparisons are easily made across datasets, data types and organisms in this unique data mining platform. A new site-wide search facilitates access for both experienced and novice users. Upgraded infrastructure and workflows support numerous updates to the web interface, tools, searches and strategies, and Galaxy workspace where users can privately analyse their own data. Forthcoming upgrades include cloud-ready application architecture, expanded support for the Galaxy workspace, tools for interrogating host-pathogen interactions, and improved interactions with affiliated databases (ClinEpiDB, MicrobiomeDB) and other scientific resources, and increased interoperability with the Bacterial & Viral BRC.

Tall buildings are one of the few constructed facilities whose design relies solely upon analytical and scaled models, which, though based upon fundamental mechanics and years of research and experience, has yet to be systematically validated in full scale. In response to this need, through the combined efforts of members of academe, a design firm and a commercial wind tunnel testing laboratory, a program was initiated to monitor the full-scale response of representative tall buildings and compare this to the predicted response from wind tunnels and finite-element models used commonly in design. As part of this monitoring program, in situ periods and damping ratios over a range of response amplitudes are also being evaluated. This paper provides an overview of the monitoring program, which includes three tall buildings in the city of Chicago, details their instrumentation and modeling, and provides an example of the full-scale response data analyses being conducted.

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