Concise and selective: the title one-pot sequence allows formation of the enone functionality and subsequent cross-coupling. The process provides access to highly functionalized cyclic enolones and enaminones from readily accessible β-heteroatom-substituted cyclic ketones.

Mit einer Tandemsequenz (siehe Schema) gelingt in einem einzigen Synthesegang die Einführung einer Enon‐Funktionalität durch Dehydrierung und die anschließende Kreuzkupplung der Zwischenstufe. Der Prozess erzeugt hoch funktionalisierte cyclische Enolone und Enaminone aus einfach zugänglichen heterocyclischen Ketonen.

Palladium-Catalyzed Dehydrogenation/Oxidative Cross-Coupling Sequence of β-Heteroatom-Substituted Ketones. -The title sequence is studied for various heterocyclic systems such as (VII), (X), (XIII) and (XV) and leads to C-3 functionalized systems. Additionally, a dehydrogenation/arylation of the chromanone scaffold (I) or (IV) becomes possible after a slight variation in the conditions to produce C-2 substituted derivatives. -(MOON, Y.; KWON, D.; HONG*, S.; Angew. Chem., Int. Ed. 51 (2012) 45, 11333-11336, http://dx.