No abstract

Previous reports showed associations between psoriasis and chronic diseases. Little is known about the association between osteoporosis and psoriasis. The goal of the study was to assess the association between psoriasis and osteoporosis in a population-based case-control study, utilizing the database of a large health-care provider organization in Israel, Clalit Health Services. Patients (aged 51-90 years) diagnosed with psoriasis were compared with a sample of age- and sex-matched enrollees without psoriasis regarding the prevalence of osteoporosis. Data on health-related lifestyles and other comorbidities were collected. The study included 7,936 psoriasis cases and 14,835 controls. The prevalence of osteoporosis was significantly greater in males with psoriasis compared with the control group (3.1 vs 1.7%, P<0.001, odds ratio (OR)=1.86, 95% confidence interval (CI): 1.44-2.39) and slightly greater in females with psoriasis (22.3 vs 20.2%, P=0.008, OR=1.13, 95% CI: 1.03-1.25). A multivariate logistic regression model demonstrated that after controlling for confounders, psoriasis was significantly associated with osteoporosis in males (adjusted OR=1.70, 95% CI: 1.31-2.19, P<0.001). The weak association between psoriasis and osteoporosis in females lost statistical significance in a multivariate model (adjusted OR=1.09, 95% CI: 0.98-1.21, P=0.100). Psoriasis was found to be associated with osteoporosis among males, but not among females.

In this large, population-based case-control study, psoriasis was found to be associated with COPD. Dermatologists caring for patients with psoriasis should be aware of this association, consult an internist or pulmonologist, and advise the patients to stop smoking and reduce additional risk factors for COPD.

Patients with psoriasis have a greater prevalence of CD than matched controls. Recent studies showed a possibility of undiagnosed CD among patients with psoriasis. Therefore, physicians treating patients with psoriasis should be aware of this possible association.

A rterial hypertension is associated with an increased risk of cardiovascular morbidity and mortality.1,2 Blood pressure (BP) reduction has been shown to reduce fatal and nonfatal outcomes in hypertensive patients. 3,4 Despite the improvement in diagnostic options and therapeutic interventions, observational studies continue to show persistently low rates of BP control in the general population of hypertensive patients. 5,6 In some of these patients, hypertension is resistant to treatment and persists despite the use of a combination of drugs. Multiple previous cross-sectional studies have consistently indicated an increased frequency of cardiovascular complications in patients with resistant hypertension (RH) compared with subjects without RH. 7-10Daugherty et al 11 in a longitudinal retrospective study found a 47% higher risk for cardiovascular complications in patients with RH compared with patients with non-RH. Studies reporting on RH have shown prevalence ranging between 3% and 38%. [7][8][9][12][13][14] However, these studies differ in the definition of RH (eg, number of drug classes included, time interval with uncontrolled BP), including or ignoring pharmacological treatment dosage and adherence to treatment, data source (eg, self-reported, physician-reported, or computerized database), method of BP assessment (eg, office or ambulatory BP monitoring), and use of a single or repeated assessments of BP. The current retrospective population-based study aimed at assessing the prevalence of RH in the hypertensive population of the Maccabi Healthcare Services (MHS) using its comprehensive computerized database, including drug dispense data. Methods Study PopulationAll data were obtained from the computerized databases of MHS. The study population included all patients aged >18 years who had entered the MHS's hypertension registry before January 1, 2010. Inclusion was based on ≥2 physician's diagnoses or hospital records and ≥2 BP measurements of systolic BP (SBP) ≥140 or diastolic BP (DBP) ≥ 90 mm Hg. For cases with abnormal measurements but no diagnoses, 4 documented measurements were required where ≥50% of the measurements were SBP >160 mm Hg or DBP >90 mm Hg. Also included were patients with ≥6 dispensed medications for hypertension. Patients were eligible for the study if they had had ≥2 BP measurements during a period of ≥6 months between January 1, 2010, and December 31, 2011. The mean (SD) number of BP measurements per patient was 3.9 (5.1). Patients who left MHS Abstract-Previous assessments of the prevalence of resistant hypertension (RH) in uncontrolled blood pressure (BP) have ranged from 3% to 30%. Using real-world data, our aim was to estimate the prevalence of RH in patients belonging to the Maccabi Healthcare Services, a 2-million-member health organization in Israel. From 2010 to 2011, all hypertensive patients with ≥2 recorded BP measurements during a minimum period of 6 months were identified. Patients were considered uncontrolled if their most recent BP during the study period and their mean...