The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to the nutritional assessment of the patient, the Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplant: Adults was prepared, aiming to standardize and update Nutritional Therapy in this area. Dietitians, nutrition physicians and hematologists from 15 Brazilian centers thar are references in hematopoietic stem cell transplant took part.

ObjectiveThis study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).MethodsA retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0).ResultsSixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9 kg/m2; 24.8 vs. 24.4 kg/m2; p-value < 0.001), and serum albumin levels (−0.2 g/dL; 3.7 vs. 3.6 g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006).ConclusionOur results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation.

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O transplante de células-tronco hematopoiéticas (TCTH) está relacionado ao desenvolvimento de diversos sintomas de impacto clínico e nutricional. Verificar as implicações clínicas e nutricionais do TCTH em crianças e adolescentes e as vias de terapia nutricional utilizadas. Foi realizada uma revisão integrativa da literatura até agosto de 2019, em três bases de dados (PubMed, Web of Science e Bireme). Foram incluídos estudos originais, disponibilizados na íntegra, publicados em português, inglês ou espanhol, que abordassem crianças e/ou adolescentes submetidos a TCTH, avaliando aspectos nutricionais em qualquer fase do tratamento. Cinco artigos cumpriram os critérios de inclusão. Observaram-se entre os estudos elevado uso de suporte nutricional e propensão à benefícios nutricionais e clínicos pela implementação da terapia nutricional. No entanto, não foi possível identificar a via de infusão mais adequada, visto também que não há consenso quanto à esta e às características dietéticas ideais para