SUMMARYComposite materials of two-dimensional structures are designed using the homogenization design method. The composite material is made of two or three di erent material phases. Designing the composite material consists of ÿnding a distribution of material phases that minimizes the mean compliance of the macrostructure subject to volume fraction constraints of the constituent phases, within a unit cell of periodic microstructures. At the start of the computational solution, the material distribution of the microstructure is represented as a pure mixture of the constituent phases. As the iteration procedure unfolds, the component phases separate themselves out to form distinctive interfaces. The e ective material properties of the artiÿcially mixed materials are deÿned by the interpolation of the constituents. The optimization problem is solved using the sequential linear programming method. Both the macrostructure and the microstructures are analysed using the ÿnite element method in each iteration step. Several examples of optimal topology design of composite material are presented to demonstrate the validity of the present numerical algorithm.

h i g h l i g h t sLow dose of perampanel (PER) is tolerable and effective to ameliorate refractory cortical myoclonus. PER suppresses and disperses paroxysmal depolarization shifts directly on the postsynaptic neurons. This action was reflected by temporal dispersion in giant SEPs (a potential clinical biomarker). a b s t r a c tObjective: To elucidate the effects of perampanel (PER) on refractory cortical myoclonus for dose, etiology and somatosensory-evoked potential (SEP) findings. Methods: We examined 18 epilepsy patients with seizure and cortical myoclonus. Based on data accumulated before and after PER treatment, correlations among clinical scores in myoclonus and activities of daily life (ADL); early cortical components of SEP; and PER blood concentration, were analyzed. Results: PER (mean dose: 3.2 ± 2.1 mg/day) significantly improved seizures, myoclonus and ADL and significantly decreased the amplitude of and prolonged latency of giant SEP components. The degree of P25 and N33 prolongations (23.8 ± 1.6 to 24.7 ± 1.7 ms and 32.1 ± 4.0 to 33.7 ± 3.4 ms) were significantly correlated with improved ADL score (p = 0.019 and p = 0.025) and blood PER concentration (p = 0.011 and p = 0.025), respectively. Conclusions: Low-dose PER markedly improved myoclonus and ADL in patients with refractory cortical myoclonus. Our results suggest that SEP, particularly P25 latency, can be used as a potential biomarker for assessing the objective effects of PER on intractable cortical myoclonus. Significance: In this study, PER lessened the degree of synchronized discharges in the postsynaptic neurons in the primary motor cortex.

No abstract