The present study indicates that Elental® is effective for ameliorating oral mucositis induced by (chemo)radiation in OSCC patients. Elental® was also associated with improved completion rates of (chemo)radiotherapy.

Oral mucositis is a common adverse effect of cancer treatment that can increase the risk for local and systemic infection. This prospective study was designed to evaluate the preventive effects of an amino-acid-rich elemental diet (ED), Elental ® , on radiotherapy-or chemoradiotherapy-induced mucositis in oral squamous cell carcinoma (OSCC) patients. Fifty patients were enrolled in this prospective study, who had received radiation (60-70 Gy) with/without chemotherapy [S-1, UFT, cisplatin (CDDP), docetaxel (DOC) plus CDDP, or Cetuximab]. The Elental ® group (25 patients) had received Elental ® during treatment, and the control group (25 patients) had not. Multivariate logistic regression analysis was used to identify the factors related to abatement of oral mucositis. A comparison of the rates of completion of chemoradiation treatments as well as the nutritional or inflammatory status between Elental ® and control groups was performed. Multivariate analysis indicated that most of the patients who received Elental ® suffered from a lower degree of mucositis and showed significantly improved rate of completion of chemoradiation (no interruption) compared to the control group. There was a significant difference between the Elental ® group and the control group in terms of the mean change of C-reactive protein (CRP) levels in blood serum; however, there was no significant difference in terms of a mean change of body weight and total protein level in blood serum before and after chemoradiation. Our study shows that the Elental ® elemental diet could be useful for the treatment of oral mucositis induced by chemoradiation. Elental ® might also promote improved completion rates of chemoradiotherapy in OSCC patients.

Mucinous adenocarcinoma (MAC) arising in the oral cavity is extremely rare. We report a case of MAC originating in the palate.A 70-year-old man presented with an ulcer of the palate visited our hospital. A demarcated tumor arising in the right side of the palate with cervical lymph swelling on the same side were recognized. Histopathological examination revealed a MAC. Partial maxillectomy and radical neck dissection were immediately performed. After surgery, neck metastasis was detected on the contralateral side. Radical neck dissection was therefore performed. After that, recurrence in the right side of the neck and lung metastasis was detected. Bilateral radiotherapy was given to treat recurrence in the neck, and chemotherapy was administered to treat the lung metastasis. The patient died of respiratory insufficiency 2 years 5 months after the first examination.

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A late foreign body reaction to a bioabsorbable poly-Llactic acid (PLLA) plate for use in orthognathic surgery is reported.A 26-year-old female was referred to our hospital in 2001 because of mandibular prognathism.Sagittal split ramus osteotomy was carried out with the use of PLLA mini-plates and screws. The postoperative course was