To date, there has been no study on the development of novel regimens based on the following tissue engineering principles: seeding and culturing mesenchymal stem cells (MSCs) on a scaffold before surgery or injecting cultured MSCs into a scaffold during surgery. The purpose of this study was to assess the in vivo osteogenic ability of scaffold/MSCs implanted beneath the periosteum of the cranial bone of rats in three different sample groups: one in which MSCs were pre-seeded and cultured on a scaffold to produce the 3-D woven fabric scaffold/MSC composite using osteo-lineage induction medium, one in which cultured MSCs produced by osteolineage induction in cell cultivation flasks were injected into a scaffold during surgery and a control group, in which only the 3-D woven fabric scaffold was implanted. The results indicate that pre-seeding MSCs on a scaffold leads to a higher osteogenic ability than injecting cultured MSCs into a scaffold during surgery.
Nanofiber web produced via mass production electrospinning has many potential applications due to its large specific area, very small pore size, and high porosity. Despite such potential, the application of nanofiber web has been limited on account of its poor mechanical properties. In our previous study, the mechanical properties of laminated nanofiber web were investigated, and it was found that the mechanical properties of nanofiber web are sufficient for use as cloth in outdoor wear if a laminating process is used in its production. In this study, we focus on the use of nanofiber web as a breathable fabric. The purpose of this study is to measure the functional properties of mass-produced nanofiber web, and then to investigate any change of those functional properties that may occur as a result of laundering. The measured functional properties include the water transfer properties of waterproofness and vapor permeability as well as the thermal transfer properties of warm/cool feeling and thermal conductivity. We conclude that the maintenance of nanofiber web morphology despite repeated laundering allows for the retention of the water and thermal transfer properties of the material.
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