Background: Profilin1 is required for actin cytoskeletal modulation. Results: Mice lacking Profilin1 in mesenchymal progenitor cells exhibit cleft sternum and delay in endochondral bone formation. Profilin1 inactivation in skeletal cells reduces motile function of skeletal cells. Conclusion: Profilin1 regulates skeletal development and facilitates skeletal cell migration. Significance: Our findings provide new insights into skeletal development based on cytoskeletal function.
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