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Diabetes is a metabolic disorder that is characterized by inadequate insulin secretion by pancreas or the lack in ability of the present insulin to function properly. Hence, diabetes forms a fertile media for several diseases and represents a greater risk on human-being health. Over decades, several strategies for management of diabetes have been tried by specialists, of which medical, herbal, and even live style modification has been tried.Although diabetes mellitus represents a global growing epidemic disease, Till the moment there is no absolute solution at molecular level that targeting the disease. It's well known that commensal bacteria have an un-neglectable role in bode metabolism since infancy both in healthy and diseased patients. On a clinical base when we studied beneficial role of probiotics at cellular level in animals. It was proved in many studies the beneficial role of probiotic for people with DM; nevertheless, further prospective interventional research, mostly using human models, are required to fully understand the impact of probiotic use in diabetic patients. Indeed, we need to test the probability of probiotics usage in the outpatient clinic. As Based on our reliable understanding the beneficial role of probiotics in patients with diabetes mellites specially at the level of cell, both in clinical trials and animal studies, in addition to their excellent tolerability. Also, probiotics have proved their ability to decrease insulin and fasting blood glucose level in diabetic patients in a preclinical setting and in human trials. Recently, probiotics are used in a multiple diseases like inflammation, allergic reactions, and autoimmune diseases. However, the heterogeneity in these studies is high. For example, species used, the dose of probiotic used, and the magnitude of efficacy.In our review, we focused on reviewing the relation between probiotics and troubled metabolism of our body sugar.

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