States. About two hundred of the species studied have not yet yielded sapogenins in our extraction experiments. The steroidal sapogenins of determined structure from other laboratories and their sources are as follows Sapogenin Plant Chlorogenin Chlorogalum pomeridianum Kiinth8•9'10 Digitogenin Digitalis purpurea11-14 Diosgenin Dioscorea tokora Makino15 Gitogenin Chlorogalum pomeridianum Kunth10 Digitalis species13,16

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To the ester (50 g.) was added 5 g. of catalyst and the mixture placed under a pressure of 1840 lb. of hydrogen. The temperature was then slowly raised. Hydrogenation of the double bond took place at*a pressure of 2550 lb. and a temperature of 146°. If the hydrogenation were interrupted at this point, an approximately quantitative yield (98%) of ethyl 2,3-dimethoxydihydrocinnamate, b. p. 174-176°at 13 mm., could be obtained.

The amount of free gastric acid secreted after methacholine stimulation was studied in anesthetized rats. Desiccated thyroid elevated the metabolic rates of normal rats 45% and reduced free acid secretion. Thyroparathyroidectomy (3–5 weeks postoperative) did not change secretion from that of controls. Thyroparathyroidectomized rats made euthyroid by thyroxine or desiccated thyroid had reduced secretions. Serum calcium was decreased in all treated groups. Serum phosphate and adrenal gland weights were increased in normal, thyroid-fed rats. Thymus gland weights were unchanged.

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