Evaluating CD200 expression has a great impact on accurate BCLPDs diagnosis and could be added to the BCLPD routine panels. The high expression of CD200 in B-cell CLL and hairy cell leukemia could open the option for targeted immune (anti-CD200) therapy.

VKORC1-TT and CYP2C9 *1/*1 are the most prevalent genotypes among Egyptians. Patients with VKORC1-TT genotype required a lower warfarin dose.

The data support the concept of chemokines (RANTES) as mediators of liver cell injury in HCV infection. In addition, MDA and NO levels might be used as monitoring markers for oxidative stress in hepatitis C infection.

Chronic infection with hepatitis C virus (HCV) is associated with failures of T-cellmediated immune clearance and with abnormal B-cell growth and activation.HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. Following viral infection, multiple pro-inflammatory mediators contribute to recruitment of immune cells to the liver and to the generation of an antiviral immune response. Recent publications mark chemokines and their receptors as key players in leukocyte recirculation through the inflamed liver. The present study involved 75 male subjects, included into two groups: Group1 (n=30) control group; group II (n=45) patients with chronic HCV. For all subjects the following investigations were performed: estimation of the levels of bilirubin, albumin, prothrombin concentration, glycosylated hemoglobin (HbA 1C), creatinine, αfetoprotein (AFP), HCV RNA, and activities of alanine and aspartate transaminases (ALT& AST) as well as alkaline phosphatase. Also, Regulated on Activation Normal T Cell Expressed and Secreted (RANTES), tumor necrosis factor alpha (TNF-α), malondialdehyde (MDA) and nitric oxide (NO) were assessed. Plasma HCV-RNA concentration (viral load) was determined by real time PCR step one using Applied Biosystem. Complete blood picture was assayed using Abbott cell dyn 3700 hematology analyzer. There were significant increase of the levels of RANTES,TNFα, MDA and NO in HCV infected patients compared with control group (P <0.05) and in these patients, these levels showed significant positive correlation with the HCV RNA viral load. Also, mild leucopenia, thrombocytopenia, neutropenia, lymphocytosis, with consequent significant increase in the lymphocytes / neutrophils (L/N) ratio were detected in these patients. Conclusion: The data support the concept of chemokines (RANTES) as mediators of liver cell injury in hepatitis C infection. In addition, MDA and NO levels might be used as monitoring markers for oxidative stress in hepatitis C infection.

The risk of developing ITP was not related to the studied polymorphism.