Bleomycin (BLM) is one of anti-cancerous drugs. One of its limitation is the development of pulmonary fibrosis during therapy So, we proposed to examine the outcome of BLM take on the light and electron microscopic design of rat lung. Along with, assessment the probable protecting role of ginsenoside on BLM induced pulmonary changes. In this study, thirty adult male albino rats were comprised and were classified to four clusters; Negative & positive control group, BLM treated group and BLM& ginsenoside treated group. The lung was treated for histological and immunohistochemical (anti-p65) studies. Light microscopic examination of H&E stained sections of BLM treated group showed huge distortion of the lung building. Mallory trichrome stain of this group showed evident deposition of collagen fibers in the markedly thickened interalveolar septa and around intrapulmonary bronchi, bronchioles and blood vessels. Moreover, strong positive staining for nuclear factor (NF)-κB in the wall of bronchiole as well as the thickened interalveolar septa were observed. Ultrastructural inspection of lung of this group revealed muddled lung planning. Marked improvement of the lung structure and marked reduction in NF-κB immunoexpression was appeared in BLM and ginsenoside treated group. So, we concluded that co-administration of ginsenoside with BLM significantly enhanced the histological and morphometric image of the lung.

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The Egyptian Journal of Histology 2012Histology , 35:761-772 68 (1387Histology -2012 lamina; they might be involved in intercellular signaling. This would indicate that these cells might modulate the parotid function. H. Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury.

BackgroundBisphenol A (BPA) is a xenoestrogen (environmental estrogens) used in the production of polycarbonate plastics and epoxy resins that line food and beverage cans. Modernization of the Arabian Gulf region has resulted in the wide consumption of readymade foods that are packed in plastic containers and cans. Consequently, the majority of humans, particularly infants and children, are being continuously exposed to it. Aim of workThe objective of the present study was to examine the effect of exposure to BPA on the testis, epididymis, prostate, and penile corpora of adult albino rat. Materials and methodsOne, 4, and 8 weeks following a subcutaneous injection of 150 µg BPA/kg body weight into adult albino rats every other day for 12 days, the histopathological changes induced in the testis, epididymis, prostate, and penile corpora were detected using both light and transmission electron microscopic techniques. ResutsIn BPA-treated animals, seminiferous tubules showed a decreased thickness of germinal epithelium with vacuolar degeneration and increased apoptotic cells. Sperm were hardly seen till the eighth week, when spermatogenesis was regained, but spermatids and mature sperm still had residual malformations. The rough endoplasmic reticulum cisternae of prostatic parenchyma appeared distended with a homogeneous content whereas most of the secretory vesicles were empty. In the penile corpora of BPA-treated groups, both tunical thickness and trabecular smooth muscle content were increased with consequent narrowing of sinusoidal spaces. ConclusionThese results suggest that BPA inhibits spermatogenesis, increases the ratio of sperm anomalies, and has a potential harmful effect on erectile function, which raises an alarm to the harmful effects of environmental contaminants that might cause subfertility or infertility.