Diazocoupling reaction of curcumin with different diazonium salts of p-toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones 2a–c. Arylhydrazone of p-toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of 2a with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1H-pyrido[2,3-b][1,4]diazepine derivative. Bis(2,5-dihydroisoxazole) is obtained from the reaction of 2a with hydroxylamine hydrochloride, while its reactions with hydrazines afforded the respective 4,5-dihydro-1H-pyrazoles. The target compounds were evaluated as antioxidant and antibacterial agents. The tested compounds showed good to moderate activities compared to ascorbic acid and chloramphenicol, respectively.

Three novel imidazolium‐based gemini surfactants had been synthesized and characterized using different spectroscopic techniques. The surface properties of the synthesized surfactants were determined using surface tension measurements at 20 °C. The surface parameters including critical micelle concentration (CMC), πCMC, Pc20, Γmax and Amin were determined. The synthesized compounds were evaluated as corrosion inhibitors for carbon steel in 0.5 M HCl solution using the weight loss and polarization techniques. The biological activity of these surfactants was evaluated against sulfate reducing bacteria using most probable number method. The results indicate that the synthesized compounds have good surface properties and are proper corrosion inhibitors for low carbon steel, with a high inhibition efficiency observed around their CMC. These compounds exhibit a significant biocidal activity against sulfate reducing bacteria.

Numerous aminothiadiazole‐based compounds have been extensively employed as pharmaceuticals to treat a variety of ailments, leading to a flurry of new discoveries. It takes novel synthetic techniques to prepare new aminothiadiazole derivatives from enaminonitrile derivative 4, which was formerly an important step in the synthesis of pyrazole, isoxazole, and pyrimidine derivatives (6, 8, and 10). For the production of triazolo, imidazolo, and pyrazolo pyrimidine derivatives, enaminonitrile 4 also has shown chemical activity toward various N‐nucleophiles, such as heterocyclic amines (12, 14, and 16). As a result of cyclo‐condensing enaminonitrile precursor 4 with a variety of carbon and oxygen nucleophiles, certain complex, polyfunctional substituted fused 2‐pyridone and chromenone derivatives containing thiadiazole molecules were produced (18, 20, 22, and 25). Next, the cytotoxic effect of the entitled compounds against HepG2 and MCF7 has been reported, followed by an in‐vivo study on hepatocellular carcinoma (HCC) HepG2 with the compounds that showed the lowest IC50 values. In addition to molecular docking into the FGFR 4 active site (PDB: 4XCU), the bioavailability of the active compounds in accordance with Lipinski's rule of five has been shown.

Hematological reference values are essential for the interpretation of the Result of laboratory tests and treatment decisions. The full blood count reference intervals in Egypt are generally derived from non-Egyptian subjects. This study aimed to establish hematological reference intervals for healthy adults in Egypt. From January 2018 to January 2020, 5620 volunteers were recruited for this study. A total of 5620 was divided into 1846 (32.8 %) males and 2926 (52.1 %) Females. but 848 (15.1 %) volunteers were excluded because of positive laboratory screening results. Males had higher median of hemoglobin (14 g/dL versus 12.3 g/dL), median of RBC (4.96 × 10 6 / µL versus 4.35 × 10 6 / µL), and hematocrit (41% versus 36.2%) than females. The difference in hemoglobin, RBC, and hematocrit by gender was statistically significantly different (p < 0.05). Males had lower median white blood cell (6.7× 10 3 / µL versus 6.9× 10 3 / µL) and median of Platelets (230 × 10 3 / µL versus 252.5 × 10 3 / µL) than Females (p < 0.05). in comparison to reference values that are commonly used in Egypt, the hemoglobin levels, RBC, and hematocrit from this study were lower.

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