Background Patients with chronic renal failure on hemodialysis suffered from many nutritional complications such as protein-energy wasting. Nutritional assessment is a basic and necessary process in the nutritional management of those patients. Nutritional assessment includes obtaining specific data to create a metabolic and nutritional profile of the patient. Aim The study aimed to assess the nutritional status among patients with chronic renal failure undergoing hemodialysis regimen. Design A descriptive research design was utilized in the study. Sample A convenient sample of 100 participants undergoing hemodialysis. Setting Data were collected from Nephrology, Dialysis, and Transplantation Center at Kaser Al-Ainy Hospital, affiliated to Cairo University hospitals. Tools Two tools were utilized to collect data: sociodemographic data sheet and comprehensive nutritional assessment sheets. Results Male and female participants nearly equal to 78% urban. Conclusion The study results revealed that the majority of study sample has many nutritional disturbances such as anemia, hypocalcemia, and decreased lean body mass. Recommendations Raising awareness of nurses who care for hemodialysis patients regarding the importance of nutritional assessment of hemodialysis patients and its application in the protocol of care.