Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 µg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies.

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Herein, Ag@CDs nanocomposites were utilized for the detection of propranolol hydrochloride (PPH). Structural characterization of the nanocomposites was performed using UV-Vis., spectroscopy, dynamic light scattering, zeta potential, and contact angle measurements. Electrochemical analysis of the prepared electrode Ag@CDs/ITO was done using electrochemical impedance spectroscopy and cyclic voltammetry. Three electrodes were fabricated on same ITO substrate through selective etching of ITO followed by deposition of different materials on each electrode. To the best of our knowledge, miniaturization of the bulky electrochemical measurement setup has not been reported yet. Moreover, the proposed setup was able to give good limit of detection of 0.38 μM and exhibited linear response in the range of 5-45 μM PPH. Also, the sensor was functional in artificial urine samples showing 80-100% recoveries. The excellent stability, repeatability, and reproducibility of the proposed sensor validate its application in real sample analysis.

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