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This paper analyzes the first-order and first-order time-delayed systems control approaches, focusing mainly on unstable systems. First, it discusses asymmetries between the disturbance observer-based (DOB) control with decoupled tracking and the disturbance rejection responses, stressing applications to stable and unstable plants. The paper analyzes some DOB-based control solutions for unstable systems which do not use internal closed-loop stabilization. The novelty of the paper is thorough study accompanied with a comprehensive explanation of the differences between two distinct approaches: the transfer-function- and the closed-loop-based feedforward control approach from the point of view of control constraints. It is clearly illustrated that the main cause of instability of DOB-based approaches, applied to unstable systems, is given by their effort to impose on the system the unstable dynamics of the chosen nominal process model. It is also shown that the closed-loop stability of the DOB-based control, applied to the unstable systems, can be restored by using the supervising reference model control (RMC). The main novelty of the proposed approach is that its eliminates the mentioned stability problems while maintaining the full functionality of the chosen control structures. RMC has so far only been implemented for generating a setpoint feedforward signal. However, by generalization of this approach for disturbance rejection, the methodology of DOB design, based on nominal models, can be extended to the control of unstable systems. Without the use of disturbance reference models, the interactions of the master stabilizer with disturbance compensation cannot be eliminated. Without the internal stabilization, the stable transients can only be achieved by designing controllers based on stable models, instead of unstable ones. The existing modifications of DOB-based schemes for unstable plants, proposed in some references, are shown to lead to traditional Proportional-Integrative (PI) control, thus losing all the advantages over the PI controllers. In all the considered structures, the role of integrating models is also emphasized.