This paper highlights detailed projected changes in rainfall over Thailand for the early (2011–2040), middle (2041–2070) and late (2071–2099) periods of the 21st century under the representative concentration pathways (RCP) 4.5 and RCP 8.5 using the high‐resolution multi‐model simulations of the Coordinated Regional Climate Downscaling Experiment (CORDEX) Southeast Asia. The ensemble mean is calculated based on seven members consisting of six general circulation models (GCMs) and three regional climate models (RCMs). Generally, the ensemble mean precipitation agrees reasonably well with observations, best represented by the Global Precipitation Climatology Center (GPCC) data, over Thailand during the historical period (1976–2005). However, inter‐model variations can be large among ensemble members especially during dry months (December to March) for northern‐central‐eastern parts, and throughout the year for the southern parts of Thailand. Similarly for future projection periods, inter‐model variations in the sign and magnitude of changes exist. The ensemble means of projected changes in rainfall for both RCPs during dry months show distinct contrast between the northern‐central‐eastern parts and the southern parts of Thailand with generally wetter and drier conditions, respectively. The magnitude of change can be as high as 15% of the historical period, which varies depending on the sub‐region, season, projection period, and RCP scenario. In contrast, generally drier conditions are projected during the wet season (June to September) throughout the country for both RCPs where the rainfall reduction can be as high as 10% in some areas. However, the magnitude of projected rainfall changes of some individual models can be much larger than the ensemble means, exceeding 40% in some cases. These projected changes are related to the changes in regional circulations associated with the winter and summer monsoons, which are projected to weaken. The drier (wetter) condition is associated with the enhanced subsidence (rising motion).

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A protocol for the identification of Ancestry Informative Markers (AIMs) from genome-wide Single Nucleotide Polymorphism (SNP) data is proposed. The protocol consists of three main steps: identification of potential positive selection regions via F(ST) extremity measurement, SNP screening via two-stage attribute selection and classification model construction using a Naïve Bayes classifier. The two-stage attribute selection is composed of a newly developed round robin Symmetrical Uncertainty (SU) ranking technique and a wrapper embedded with a Naïve Bayes classifier. The protocol has been applied to the HapMap Phase II data. Two AIM panels, which consist of 10 and 16 SNPs that lead to complete classification between CEU, CHB, JPT and YRI populations, are identified. Moreover, the panels are at least four times smaller than those reported in previous studies. The results suggest that the protocol could be useful in a scenario involving a larger number of populations.

This article presents the ability of an omnibus permutation test on ensembles of two-locus analyses (2LOmb) to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evaluated in various simulation scenarios covering two independent causes of complex disease where each cause is governed by a purely epistatic interaction. Different scenarios are set up by varying the number of available single nucleotide polymorphisms (SNPs) in data, number of causative SNPs and ratio of case samples from two affected groups. The simulation results indicate that 2LOmb outperforms multifactor dimensionality reduction (MDR) and random forest (RF) techniques in terms of a low number of output SNPs and a high number of correctly-identified causative SNPs. Moreover, 2LOmb is capable of identifying the number of independent interactions in tractable computational time and can be used in genome-wide association studies. 2LOmb is subsequently applied to a type 1 diabetes mellitus (T1D) data set, which is collected from a UK population by the Wellcome Trust Case Control Consortium (WTCCC). After screening for SNPs that locate within or near genes and exhibit no marginal single-locus effects, the T1D data set is reduced to 95,991 SNPs from 12,146 genes. The 2LOmb search in the reduced T1D data set reveals that 12 SNPs, which can be divided into two independent sets, are associated with the disease. The first SNP set consists of three SNPs from MUC21 (mucin 21, cell surface associated), three SNPs from MUC22 (mucin 22), two SNPs from PSORS1C1 (psoriasis susceptibility 1 candidate 1) and one SNP from TCF19 (transcription factor 19). A four-locus interaction between these four genes is also detected. The second SNP set consists of three SNPs from ATAD1 (ATPase family, AAA domain containing 1). Overall, the findings indicate the detection of pure epistasis in the presence of genetic heterogeneity and provide an alternative explanation for the aetiology of T1D in the UK population.