A strategy for the synthesis of 2,3-disubstituted indoles from 2-allyl-2-(2-nitrophenyl)cyclohexane-1,3-dione has been developed. A wide array of 2,3-disubstituted indoles were accessed in modest to good yields via a tandem reduction/condensation/fragmen-tation/cyclization...
A chiral phosphoric acid (CPA)‐catalyzed enantioselective Pictet–Spengler condensation/lactamization cascade reaction was established, which paved the way of the collective synthesis of iboga‐type indole alkaloids. Herein, we presented the asymmetric total synthesis of iboga‐type indole alkaloid (+)‐tabertinggine.
An efficient approach for the synthesis of the 9/6/6 tricyclic structure ofLycopodiumalkaloid palhinine A has been accomplished. This protocol can undergo ring constriction to rapidly construct the highly strained nine-membered azonane ring of palhinine A.
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