Suicide is the second leading cause of death for traditional-age college students, and the interpersonal theory of suicide (ITS; Joiner, 2005) provides a cogent framework for predicting which students may be at highest risk. However, little is known about how constructs of ITS operate in cross-cultural contexts. Findings, based on a sample of international and domestic undergraduate students (N = 254), indicated that the ITS construct of perceived burdensomeness was positively associated with suicidal ideation (SI) for both groups. However, campus belongingness emerged as connected with SI for international students, whereas family belongingness emerged as connected with SI for domestic students.