Cp*Cobalt­(III)-catalyzed enantioselective C–H amidation of ferrocenes using monoprotected amino acids (MPAAs) as chiral ligands was developed. The reaction was performed under mild conditions in high yields (up to 97%) with moderate enantioselectivity (up to 77.5:22.5 er), providing a promising strategy to create planar chirality via base-metal-catalyzed enantioselective C–H activation.

Dibenzocyclooctadiene lignans are an interesting class of molecules because of their unique structure based on an axially chiral biaryl moiety as well as their significant biological activity. Herein, we describe the development of a palladium-catalyzed atroposelective C-H alkynylation and its application in gram-scale, stereocontrolled formal syntheses of (+)-isoschizandrin and (+)-steganone. tert-Leucine was identified as an efficient, catalytic transient chiral auxiliary. A wide range of enantiomerically enriched biaryl compounds were prepared by this approach in good yields (up to 99 %) with excellent enantioselectivity (up to >99 % ee).

The amide-directed cobalt­(III)-catalyzed C–H amidation of ferrocene carboxamides using 1,4,2-dioxazol-5-ones as robust and efficient amidating reagents has been developed. This reaction proceeds efficiently under mild reaction conditions with good functional group tolerance, providing expedient access to a broad range of ferrocenes containing a nitrogen group on the Cp ring.

Dibenzocyclooctadiene lignans are an interesting class of molecules because of their unique structure based on an axially chiral biaryl moiety as well as their significant biological activity.H erein, we describe the development of ap alladium-catalyzed atroposelective C À Ha lkynylation and its application in gram-scale,stereocontrolled formal syntheses of (+ +)-isoschizandrin and (+ +)-steganone.t ert-Leucine was identified as an efficient, catalytic transient chiral auxiliary.A wide range of enantiomerically enriched biaryl compounds were prepared by this approachi ng ood yields (up to 99 %) with excellent enantioselectivity (up to > 99 %ee).Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

The Ru-catalyzed meta-C-H benzylation of arenes bearing pyridyl, pyrimidyl, and pyrazolyl directing groups with toluene derivatives has been reported. Heptafluoroisopropyl iodide (CFI) was employed as both a mild oxidant and radical initiator. This reaction showed excellent site-selectivity and tolerated a wide range of functional groups, providing a new strategy for the synthesis of various diarylmethane moieties.