The main goal of this study is to examine how empowerment, information systems, and agile leadership affect organizational entrepreneurship in the Zain telecommunications company. After the sample-checking procedure, 223 samples were collected. The research investigation processed all the data gathered using the PLS program. The research's conclusions show several connections and interconnections that may impact improving organizational entrepreneurship. The study findings show that agile leadership, including inclusive leadership, shared accountability, and collaborative decision-making has a favorable direct impact on entrepreneurship. The outcome indicated that information systems, including system flexibility, shared information and reports, authorization, speed, and enterprise computing, benefit entrepreneurship. The outcome also demonstrated that empowerment has direct and advantageous effects on entrepreneurship, including certifications relating to quality, rejection rates, past performance, and competence. There was a discrepancy between the research findings and those of other studies, which found no connection between the factors and e-learning satisfaction and entrepreneurship. This study suggests that for businesses to deal with information systems effectively, keep up with change and competition, gain more competitive advantages, develop new knowledge, and support and enhance the decision-making process, they must begin the process of entrepreneurship for all business transactional processes, documents, and orders. The uniqueness of this study creates a framework for emphasizing the essential contributions that an information system, an empowered workforce, and agile leadership can make to foster organizational entrepreneurship.