Field experiments were conducted between April and November 2016 at the Teaching and Research Farm of Ibrahim Badamasi Babangida University, Lapai (Latitude 09 0 02 " N and Longitude 06 0 34 " E) and Research Farm of College of Agriculture, Mokwa (Latitude 09 08''N and Longitude 05 0 04''E) to examine the effects of poultry manure time of application on the growth and yield of water melon varieties. The experiment was a 4 x 3 factorial laid in a Randomized Complete Block Design (RCBD) replicated three times. The treatments consisted of four (4) varieties of water melon and three (3) different times of application of poultry manure; a week before planting, during planting and a week after planting. The poultry manure was applied to all the treatments at the rate of 10 tonnes per hectare. Parameters evaluated were vine length per plant (cm), number of leaves per plant, number of branches per plant, days to first flowering, days to 50% flowering, number of fruits per plant, weight of fruits per plant (kg) and fruit yield (t/ha). Data collected were subjected to analysis of variance (ANOVA), significant means were separated using Least Significant Difference (LSD 0.05 ). The results indicated that, out of the four varieties evaluated, variety Koloss F 1 , and Kaolak significantly produced longest vine, higher number of leaves and branches, higher number of fruits per plant, heavier fruits weight per plant and higher yield (t/ha). Also the application of poultry manure at a week before planting significantly supported higher growth rate and yield in all the four water melon varieties evaluated. Based on the outcome of this research, Koloss F 1 and Kaolak varieties planted in the plots with the application of poultry manure a week before planting showed appreciable growth responses at the two locations considered.