Minor salivary gland cancer is a relatively uncommon disease of head and neck, arising across the upper aerodigestive tract. This is a malignant neoplasm with diverse clinical behaviors and histological types which are prognostically significant. Although complete surgical resection, with adequate free margin, is currently the treatment of choice for locoregional diseases, the optimal treatment is still not standardized. We presented here a case of locally advanced minor salivary gland cancer that was treated by radical resection, reconstruction, and adjuvant radiation therapy at Vietnam National Cancer Hospital and had promising outcomes.

Nasopharyngeal carcinoma (NPC) is amongst the most common malignancies of head and neck cancers. Most patients are admitted to the hospital with advanced disease. NPC has a tendency toward early metastatic spread to cervical lymph nodes, and levels II and III are most commonly involved. A few reports have indicated specific metastatic sites of nasopharyngeal cancer, including lymph node metastasis and distant metastasis. Evidence of histopathology and immunohistochemistry is required to prove NPC origin. In many cases, surgery can be performed to obtain accurate evidence of the pathology. However, surgery can also affect the overall treatment plan and strategy for NPC and should be considered in the specific circumstances of the disease. Multidisciplinary consultation is required for these uncommonly specific metastases. Paying attention to the specific lymph node metastasis sites of NPC plays an important role in accurately diagnosing the stage, thereby giving an appropriate treatment strategy. It is also important in determining radiotherapy volumes because radiotherapy is the standard therapy for this disease. Herein, we are reporting 2 cases of NPC with clinical metastasis to unusual lymph node sites such as the parotid salivary gland and the cheek. Histological analyses from the resected specimens confirmed its nasopharyngeal origin. Lymph node metastases in the parotid gland and the cheek are unusual. In diagnosis and follow-up, it is necessary to evaluate carefully to make an accurate diagnosis and appropriate treatment plans for patients as well as early detect recurrent metastases at uncommon sites of lymph nodes.

Background: CASTLE (Carcinoma showing thymus-like differentiation) in thyroid gland is a rare disease with favorable prognosis. Treating with surgery and adjuvant radiation therapy has been reported to be able to improve local controlling and long – term survival rates. In this report, we give an account of a clinical case of thyroid gland CASTLE and include relevant literature review in diagnosis and treatment of this disease.Case presentation: A 60-year-old female patient diagnosed with Castle in 2015, had a total thyroidectomy and hormone maintenance. After 5 years, the patient was diagnosed with recurrence, late stage and incapable of surgery. Due to the refusal of radiation therapy, the patient is followed and is currently stable after 15 months.Conclusions: CASTLE is a rare disease, diagnosis is based on postoperative pathology and immunohistochemistry analysis, especially upon CD5 marker. In the case of relapse, treatment includes surgery and radiation therapy. In some cases, follow-up is also an acceptable option for the patient.