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Using both pH potentiometry and spectrophotometry, aqueous complex formation constants have been measured over a range of temperatures for both cyclohexa-amylose (a-cyclodextrin) and cycloheptaamylose (P-cyclodextrin) with substrates amantadine (adamantan-1 -ylamine) and amantadine hydrochloride. Both forms of cycloamylose complex with either amantadine or the hydrochloride with 1 : 1 stoicheiometry and cyclohexa-amylose complexes with amantadine with 2 : 1 stoicheiometry also. The formation constants for the cyclohepta-amylose adducts are unusually strong, ca. I x l o 5 and 1 x l o 4 for amantadine and the hydrochloride, respectively. Enthalpies and entropies of formation are estimated for each complex from the temperature dependence of the equilibrium constants. These