In this study, we demonstrated the ability of MRI to noninvasively monitor injury and recovery in the peripheral nervous system, by demonstrating changes in nerve and muscle that correlated with histological and behavioral evidence of axonal degeneration and regeneration. This study demonstrates the potential of MRI to distinguish traumatic peripheral nerve injuries that recover through axonal regeneration (i.e., axonotmetic grade) from those that do not and therefore require surgical repair (i.e., neurotmetic grade). This diagnostic modality could improve treatment by providing earlier and more accurate diagnoses of nerve damage, as well as reducing the need for exploratory surgery.

In this work we propose a macroscopic model for studying routing on networks shared between human-driven and autonomous vehicles that captures the effects of autonomous vehicles forming platoons. We use this to study inefficiency due to selfish routing and bound the Price of Anarchy (PoA), the maximum ratio between total delay experienced by selfish users and the minimum possible total delay. To do so, we establish two road capacity models, each corresponding to an assumption regarding the platooning capabilities of autonomous vehicles. Using these we develop a class of road delay functions, parameterized by the road capacity, that are polynomial with respect to vehicle flow. We then bound the PoA and the bicriteria, another measure of the inefficiency due to selfish routing. We find these bounds depend on: 1) the degree of the polynomial in the road cost function and 2) the degree of asymmetry, the difference in how human-driven and autonomous traffic affect congestion. We demonstrate that these bounds recover the classical bounds when no asymmetry exists. We show the bounds are tight in certain cases and that the PoA bound is order-optimal with respect to the degree of asymmetry.

We study routing behavior in transportation networks with mixed autonomy, that is, networks in which a fraction of the vehicles on each road are equipped with autonomous capabilities such as adaptive cruise control that enable reduced headways and increased road capacity. Motivated by capacity models developed for such roads with mixed autonomy, we consider transportation networks in which the delay on each road or link is an affine function of two quantities: the number of vehicles with autonomous capabilities on the link and the number of regular vehicles on the link. We particularly study the price of anarchy for such networks, that is, the ratio of the total delay experienced by selfish routing to the socially optimal routing policy. Unlike the case when all vehicles are of the same type, for which the price of anarchy is known to be bounded, we first show that the price of anarchy can be arbitrarily large for such mixed autonomous networks. Next, we define a notion of asymmetry equal to the maximum possible travel time improvement due to the presence of autonomous vehicles. We show that when the degree of asymmetry of all links in the network is bounded by a factor less than 4, the price of anarchy is bounded. We also bound the bicriteria, which is a bound on the cost of selfishly routing traffic compared to the cost of optimally routing additional traffic. These bounds depend on the degree of asymmetry and recover classical bounds on the price of anarchy and bicriteria in the case when no asymmetry exists. Further, we show with examples that these bound are tight in particular cases.

Traffic congestion has large economic and social costs. The introduction of autonomous vehicles can potentially reduce this congestion, both by increasing network throughput and by enabling a social planner to incentivize users of autonomous vehicles to take longer routes that can alleviate congestion on more direct roads. We formalize the effects of altruistic autonomy on roads shared between human drivers and autonomous vehicles. In this work, we develop a formal model of road congestion on shared roads based on the fundamental diagram of traffic. We consider a network of parallel roads and provide algorithms that compute optimal equilibria that are robust to additional unforeseen demand. We further plan for optimal routings when users have varying degrees of altruism. We find that even with arbitrarily small altruism, total latency can be unboundedly better than without altruism, and that the best selfish equilibrium can be unboundedly better than the worst selfish equilibrium. We validate our theoretical results through microscopic traffic simulations and show average latency decrease of a factor of 4 from worst-case selfish equilibrium to the optimal equilibrium when autonomous vehicles are altruistic.

Transcutaneous ultrasound applied to an animal model of axonotmetic injury accelerated recovery. Future studies should focus on identification of the mechanism(s) by which ultrasound creates this effect, as a prelude to optimization of the protocol, demonstration of its safety, and its eventual application to humans.