The aim of this study was to find out motivation for occupational preference among Regional Maritime University students. The cross-sectional survey design was chosen for the study and the stratified sampling technique was used to select a sample of 305 students from three departments constituting major programmes of study. Motivation for Occupational Preference Scale was used to gather data from the sampled population. The Independent samples t-test and Analysis of Variance (ANOVA) were used to analyze the data gathered. Results showed that, extrinsic values influenced occupational preference more than intrinsic values, both Ghanaian and International students were influenced equally by extrinsic factors in their preference for occupation, there was no significant gender difference in the influence of extrinsic factors on occupational preference and there was a significant difference in the intrinsic factors that influence occupational preference among students from different programmes. It is therefore recommended that, regular career guidance and counselling sessions are held at various levels of education to inform and educate students especially at the university on the benefits of career preference based on intrinsic factors than solely on extrinsic factors. In conclusion students must be encouraged to assess their vocational interest or career preference so that they pursue programmes and courses that they have the natural inclination for and not only make a choice of vocation or career just for extrinsic values or rewards.