Calciphylaxis has high mortality. Vitamin K deficiency is common in haemodialysis patients and may be a trigger for calciphylaxis due to its role in activating matrix Gla protein (a tissue inhibitor of calcification). We report the case of a 43-year-old female haemodialysis patient who developed calciphylaxis. Two months prior to the diagnosis she was found to have an undetectable plasma vitamin K concentration. The calciphylaxis completely resolved with vitamin K supplementation and an increase in haemodialysis frequency. She did not receive sodium thiosulphate or bisphosphonates. Supplementation of vitamin K in deficient patients may improve the outcome of this condition.

Aim: Kinetic estimated Glomerular Filtration Rate (KeGFR) approximates GFR under non-steady-state conditions. We investigated whether the ratio of KeGFR difference to baseline eGFR could predict acute kidney injury (AKI) earlier than a creatininebased algorithm that triggered an AKI electronic Alert (eAlert).Methods: This retrospective, single-centre, proof-of-concept cohort study assessed all patients diagnosed with AKI by an automated serum creatinine-based eAlert. The kinetic eGFR, the kinetic eGFR difference from baseline and the ratio of difference to baseline was calculated in subjects with at least two serum creatinine (sCr) measurements within 72 h of AKI.Results: Patients in the AKI cohort (n = 140) had a significant decline in KeGFR ratio (AKI: 17% IQR 7% to 29%, Non-AKI: 0 IQR À12% to 9%; P-value <.0001). A decrease of the ratio greater than 10% predicted AKI with a sensitivity of 66%, a specificity of 77%, a positive predictive value of 63%, and negative predictive value of 80%. The median lead time between KeGFR ratio decrease and AKI was 24 h (IQR: 19-27 h).Conclusions: KeGFR ratio is a cheap, simple method that predicted AKI 24 h before laboratory detection. KeGFR may facilitate triaging patients to increased monitoring or intervention.

36 sessions in 5 patients were performed. No patients developed symptomatic hypocalcaemia and no patient had a recorded ionized calcium below 0.81 mmol/L. Filter clotting occurred in 2 sessions. The mean net calcium gained was 9.6±1.8 mmol per session CONCLUSION: Regional citrate anticoagulated membrane separation plasma exchange can be performed safely and effectively without the need for post filter ionized calcium monitoring. The algorithm employed resulted in a net calcium gain.

Background Kidney Functional Reserve (KFR), the only clinical kidney stress test, is not routinely measured because complexity of measurement has limited clinical application. We investigated the utility of plasma cystatin C (CysC) after oral protein loading to determine KFR in stage 3 and 4 CKD. Methods Following a 24 hour low protein diet, KFR was measured after oral protein by hourly plasma CysC and compared with simultaneous creatinine clearance (CrCl) and radionuclide Tc-99m-DTPA (mGFR) measurement in an observational, single-centre cohort study of adults with CKD 3 and CKD 4. Subjects were followed for three years for fast (F) or slow (S) CKD progression, dialysis requirement or death or a combination of major adverse kidney events (MAKE-F or -S). Result CysC, CrCl and Tc-99m DPTA mGFR measurements of KFR in 19 CKD 3 and 21 CKD 4 patients yielded good agreement. KFR was not correlated with baseline kidney function. Eight CKD 3 (42%) and 11 CKD 4 (52%) subjects reached their lowest serum CysC concentration four hours after protein loading. CysC KFR and baseline serum creatinine (sCr) predicted (death or dialysis) or MAKE-F with respective AUC = 0.73 (95% CI: 0.48 to 0.89) and 0.71 (95% CI: 0.51 to 0.84). Including CysC KFR, age, baseline sCr and nadir CysC predicted a decrease in sCr-eGFR greater than 1.2 mL/min per year (MAKE-S) with AUC = 0.89. Conclusions Serial CysC avoided timed urine collection and radionuclide exposure and yielded equivalent estimates of KFR. Serial CysC may facilitate monitoring of KFR in clinical practice.