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Objective: The aim of this study was to assess the occurrence of metabolic syndrome (MetS), obesity, and abdominal obesity during the first year after a diagnosis of breast cancer. Methods: This prospective observational study included women with a recent diagnosis of breast cancer. Women aged ≥40 years, with a recent diagnosis of breast cancer, were included. The clinical, anthropometric, and biochemical analyses were performed. Women with three or more diagnostic criteria were considered with MetS as follows: waist circumference (WC) > 88 cm; triglycerides (TG) ≥150 mg/dL; high-density lipoprotein 30 kg/m2 and abdominal obesity with WC >88cm. The measurements were carried out in three moments: first medical assessment (T0m), six months (T6m), and 12 months later (T12m). All patients underwent the interdisciplinary assessment (i.e., nutritional and psychological) at T0m. For statistical analysis, the ANOVA with repeated measures and the chi-square test of trend were used. Results: A total of 72 women with breast cancer were included, with a mean age of 58.4±10.7 years. In the assessment of MetS, BMI, and WC, no difference was observed in the occurrence between the three moments. When comparing the individual metabolic syndrome criteria between the three moments, there was only a statistical difference in the TG and glycemia criteria. The analysis of blood glucose showed a decrease in mean values, with a value of 106.6 mg/dL-T0m, 100.46 mg/dL-T6m, and 98.96 mg/dL-T12m (p=0.004). Regarding TG, an increase in mean values was observed, with a value of 121 mg/dL-T0m, 139.4 mg/dL-T6m, and 148.46 mg/dL-T12m (p=0.003). No cancer treatment showed an impact on the measured criteria. Conclusion: The interdisciplinary approach on the breast cancer survivors demonstrated a positive impact on the control of metabolic syndrome, obesity, and abdominal obesity on the first year of follow-up. Additionally, glycemic indices showed a significant decrease, but an increase in TG values was observed.

Objective: To evaluate the association between metabolic syndrome (MetS) and the immunohistochemical profile of breast cancer (BC) in postmenopausal women.Methods: This cross-sectional cohort study included 189 women, aged 45-75 years and amenorrhea > 12 months, with newly diagnosed BC and no previous cancer treatment. Clinical, anthropometric and biochemical (total cholesterol, HDL, LDL, triglycerides, and glucose) data were collected, as well as data on BC (histopathology, grade, tumor stage, lymph node metastasis hormone status (estrogen receptor, ER; progesterone receptor, PR; human epidermal growth factor receptor 2, HER-2), and epithelial proliferative activity (Ki-67). Tumors were divided into five subtypes: luminal A, luminal B HER-2 negative, luminal B HER-2 positive, non-luminal HER-2, and triple negative. Women with three or more of the following criteria were diagnosed with MetS: waist circumference ≥ 88 cm; triglycerides ≥ 150 mg/dL; HDL-cholesterol < 50 mg/dL; blood pressure ≥ 130/85 mmHg; glucose ≥ 100 mg/dL. The Student t-test, gamma distribution (asymmetric variables), chi-square test, and logistic regression (odds ratio, OR) were used for statistical analysis.Results: Sixty-three (33.3%) of the 189 patients had MetS at the time of diagnosis. The mean age, time since menopause and BMI were 59.0 ± 10.6 years, 11.4 ± 9.6 years and 28.5 ± 5.5 kg/m2, respectively, without difference between women with and without MetS (control). Women with MetS had a higher frequency of tumors ≤ 2 cm than women without MetS (49.2% vs 31.8%) (p=0.038). There were no differences in histological grade, staging, or axillary lymph node metastasis (p>0.05). The proportion of PR-positive (p=0.006), HER-2-negative (p=0.034), and luminal B HER-2-negative tumors was higher among patients with MetS (p=0.038) compared to women without MetS (79.4% vs 61.8%, 89.9% vs 78.6% and 44.5% vs 27.8%, respectively). Multivariate analysis adjusted for age, time at menopause and BMI showed a higher risk for luminal B HER-2-negative tumors among women with MetS (OR 2.00, 95% CI 1.03-3.89), obese patients (OR 2.03, 95% CI 1.06-3.90), and women with abdominal obesity (OR 1.96, 95% CI 1.01-4.03). The other BC subtypes were not associated with MetS or its components.Conclusion: In postmenopausal women with newly diagnosed BC, the presence of MetS was associated with a more favorable immunohistochemical profile of BC, such as a smaller tumor size, PR-positive and HER-2-negative status, and the luminal B tumor subtype. Citation Format: Andre Hideo Motoki, Daniel de AraujoBrito Buttros, Ana LuisaCamolezi Gaspar, Eduardo Carvalho Pessoa, Benedito de Sousa Almeida Filho, Jorge Nahas Neto, Heloisa de Luca Vespoli, Eliana AguiarPetri Nahas. Association between metabolic syndrome and immunohistochemical profile at breast cancer diagnosis in postmenopausal women [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS7-76.