Communication skills are important for physicians, as they are continuously in contact with human beings—patients, families, or members of healthcare teams—in various circumstances. At Universidad de los Andes' School of Medicine, these skills are a fundamental part of the curriculum and the subject of two undergraduate concentration courses. The purpose of this chapter is to present the experience of transitioning one of these courses, Communication Skills II, from face-to-face to a virtual learning environment as a response to the COVID-19 pandemic. It describes the rationale behind teaching communication skills, illustrates how the course was developed and taught face-to-face, presents the challenges posed the COVID-19 pandemic, explains the transition of the course to a virtual learning environment, and concludes by offering an overview of the evaluations and perceptions of the course, as taught in the virtual environment, by those involved in it.