Purpose To assess persistent and de novo rates of overactive bladder (OAB) and urgency urinary incontinence (UUI) in patients with incontinence after prostate treatment (IPT) focusing on differences between surgical intervention vs radiation. Methods We performed a retrospective review of 79 patients who underwent primary artificial urinary sphincter (AUS) placement and activation from a single surgeon between February 2012 and November 2017. Four patients with neurogenic bladder were excluded and two with insufficient follow‐up. The primary outcome measures were persistent OAB, persistent UUI, and pad usage before and after AUS placement. Results After activation of the AUS, 67% of non‐radiated patients had resolution of urgency incontinence vs only 31% of the radiated patients (P = .096). After activation of the AUS, resolution of OAB symptoms was more common in the non‐radiated group. We found 53% of the non‐radiated group vs only 22% of the radiated group had resolution of their urinary urgency (P = .045). Previous history of radiation was a risk factor for OAB after implantation of AUS (odds ratio [OR], 3.63; P = .010). Postoperative oral medical pharmacotherapy for OAB was higher in those with previous radiation vs those without prior radiation (66.7% vs 25.7%, P = .001). A history of OAB or UUI did not affect social continence after AUS placement. Conclusion Radiation is a risk for continued OAB after AUS activation. Appropriate counseling is necessary pre‐ and postoperatively to manage patient expectations and provide additional medical therapies. Mixed urinary incontinence or OAB symptoms should not exclude patients from undergoing AUS placement.
INTRODUCTION AND OBJECTIVES: There remains lack of agreement on the optimal mpMRI prostate cancer scoring system with recent UK consensus recommending use of 5-point Likert assessment rather than PI-RADS. Using a paired cohort study design we compared clinical validity and utility of both scoring systems in the detection of clinically significant (cs) and insignificant (ci) prostate cancer (PCa).METHODS: 329 pre-biopsy mpMRI scans in consecutive patients underwent prospective paired reporting using both Likert and PI-RADS (v2) by expert uro-radiologists. Patients were offered biopsy for any Likert or PI-RADS score !3; a score of 3 required PSAdensity !0.12ng/ml/ml. Utility was evaluated in terms of proportion biopsied, and proportion of csPCa and ciPCa detected. In those patients biopsied, overall accuracy of each system was assessed using receiver operating characteristic (ROC) curves. The primary threshold of csPCa was Gleason !3þ4; secondary thresholds of !Gleason 4þ3, Ahmed/UCL1 (Gleason !4þ3 or maximum cancer core length (CCL) !6 or total CCL !6) and Ahmed/UCL2 (Gleason !3þ4 or maximum CCL !4 or total CCL !6) were also used.RESULTS: Median age was 66 (IQR: 13) and PSA was 8 (IQR: 6). A similar proportion of men met the biopsy threshold and underwent biopsy in both groups (69.3% vs. 75.7%). Likert predicted more csPCa than PI-RADS across all disease thresholds. Rates of ciPCa were comparable in each group (Table 1). ROC analysis of biopsied patients showed that, although both scoring systems performed well as predictors of csPCa, Likert exhibited higher areas under the curve (AUC) than PI-RADS across all thresholds (Table 2).CONCLUSIONS: Both scoring systems demonstrated good diagnostic performance. Overall, Likert was superior by all definitions of csPCa. It has the advantages of being flexible, intuitive and allows inclusion of clinical data. We recommend that its use be considered once radiologists have developed sufficient experience in reporting prostate mpMRI.
INTRODUCTION AND OBJECTIVE: The American Urologic Association (AUA) proposed a minimum data set to be reported for peer-reviewed surgical literature regarding female stress urinary incontinence (SUI) surgical outcomes in 1997. Ten years following this publication, a review suggested that adherence to these parameters was suboptimal1. With the updated AUA/SUFU female SUI guidelines in 2017, we aimed to assess more contemporary adherence among recently published literature with respect to the original proposed minimum data set.METHODS: A literature search through Pubmed and MUSC OVID databases was conducted using terms 'stress urinary incontinence', 'surgery' and 'female' from January 2005 to December 2020 and cross-referenced this list with the AUA/SUFU SUI Guidelines literature list. Articles were excluded if they did not report on surgical outcomes, or if they reported on males, nonhumans, or pediatric populations, case reports or series, reviews or meta-analyses, and articles focused on diagnosis, or complications, or neurogenic or detrusor related incontinence. Articles were reviewed for the previously defined 22 parameters recommended to be included in SUI surgical outcomes literature such as length of follow up, definition of success, and adverse events. A data point was considered fulfilled if there was any mention or reference to it in any section of the paper. Each article received a compliance score as the percentage of parameters met out of the 22.RESULTS: 371 articles met the inclusion criteria. The average article compliance score was 62%. There were no articles that were 100% compliant with all of the suggested parameters. The parameters with the highest adherence rates of the published articles were history on the pretreatment evaluation (97%), criteria for success (95%), and complications (90%). The parameters with the lowest adherence rates were preoperative urodynamics (9%), minimum follow-up > 48 months (11%) and postoperative diary (15%). There were similar rates of overall compliance scores between articles published before and after the SUFU/AUA 2017 guidelines were published (61% vs. 63%). There was an increase usage of QoL questionaries' for post-operative evaluation (85% pre vs. 94% post) and increase usage of postoperative physical exam (67% pre vs 78% post).CONCLUSIONS: Adherence to reporting the proposed minimum data set for literature regarding female SUI surgical outcomes has remained largely suboptimal. The lack of compliance may suggest a role for a more stringent editorial review process or alternatively that these defined data points are overly burdensome or not relevant.
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