Introduction: It is possible assuming that thrombophilias can change the optimal placental function, as well as lead to infarctions, impaired maternal-fetal exchange mechanisms and even to fetal death. Placental hypoxia determines a vicious cycle comprising oxidative stress, vasoconstriction and impaired fetal oxygenation. Prophylactic heparin use throughout pregnancy has been recommended in some thrombophilia cases because it acts on the coagulation cascade. However, although heparin does not cross the placental barrier and is safe for the fetus, not all patients can use it. Its administration route (parenteral) is not practical and even its prophylactic use is not necessarily harmless, as seen in different thrombocytopenia, gastrointestinal and cerebral bleeding reports. Thus, finding clinical alternatives for these pregnant women would help significantly improving the current medical practice. The use of essential fatty acids (EFAs) is a new perspective that appears to be applicable in daily medical practice, because it facilitates the blood flow and tissue oxygenation, since they reduce vascular resistance and platelet aggregation. Methods: This study is a randomized, controlled, unblind, parallel, three-arm, open-label prevention trial conducted with pregnant women diagnosed with thrombophilia, who were treated in the Obstetrics Services of University Hospitals belonging to UFJF and to Medical School of Barbacena. All the patients were divided in two groups: Group 1=Hereditary thrombophilia patients who used 40 mg of heparin/day (enoxaparin) from the 6th pregnancy week on; Group 2 Patients with acquired or hereditary thrombophilias associated with risk factors for preeclampsia, according to ACOG19 (chronic kidney disease, previous diabetes mellitus, chronic arterial hypertension and collagenoses). Results: The current study assessed 38 pregnant women. Patients' mean age was 32.9 ± 5.0 years. The pulsatility index in the second gestational trimester (24 to 28 weeks) was compared based on treatments. Patients treated with the H+ASA+omega association recorded the lowest pulsatility index; however, there was not statistically significant difference between groups (p>0.05). Uterine artery resistance index in the second gestational trimester (24 to 28 weeks) was also compared based on treatments. Patients treated with the H+ASA+omega association recorded the best resistance index, however, there was not statistically significant difference between groups (p>0.05). The group treated only with heparin recorded the lowest fetal weight, although there was not statistically significant difference between groups. Conclusion: Our results are preliminary, and a crude evaluation of the data shows a decrease in the pulsatility and resistance indices of the uterine art. With the increase of patients in the analysis, we hope that the statistical results can demonstrate this improvement of placental flow.

O cuidado paliativo (CP) é uma ferramenta empregada para aliviar sintomas dos pacientes que possuem diagnósticos de doenças incuráveis, proporcionando uma melhor qualidade de vida em todos os aspectos, sendo ela física, espiritual, mental e social. O objetivo do presente trabalho é fazer uma revisão da literatura acerca de como a abordagem holística aos pacientes em cuidados paliativos e seus familiares é de extrema importância. Observase que a comunicação é uma ferramenta imprescindível entre as equipes de saúde e o doente/familiar no que diz respeito, principalmente, ao prognóstico, ou seja, o entendimento por parte do enfermo da sua perspectiva de vida. Aliado a isso, a espiritualidade tem se mostrado bastante eficaz na aceitação em relação ao fim da vida pelo paciente. Porém, ainda há muito que as equipes de saúde possam evoluir e tratar a morte como algo natural de todo ser humano, conversando com as famílias e preparandoas para o luto. Dessa forma, torna-se necessário que as conversas sobre fim de vida sejam cada vez mais efetivas, e que os profissionais da área tenham preparo suficiente, fazendo com que os familiares e enfermos entendam o verdadeiro sentido da finitude e não sofram de maneira avassaladora.

Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).