Original citation:Leng, Daniel J., Black, Conor and Pattison, Graham. (2015) One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process. Organic and Biomolecular Chemistry. Permanent WRAP url: http://wrap.warwick.ac.uk/75788 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-forprofit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.

The characterisation of scleric acid, a new natural product from a silent and cryptic gene cluster from genetically intractable bacteria, and its biosynthesis are reported.

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.