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For infants ≤32 weeks, RALIS detects systemic inflammatory responses in LOS and NEC in the first month of life. The algorithm can identify infection earlier than clinical suspicion, even for NEC with negative cultures. RALIS has high NPV to rule-out LOS and NEC, and may, after prospective validation, aid in antibiotic treatment decisions.

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The preparations and some pharmacological properties of 70 aralkyl hydrazines and acylated hydrazines are described. From the data obtained attempts were made to correlate activity with structure. Several highly efficient monoamine oxidase inhibitors were uncovered and presently are undergoing additional laboratory and clinical tests.During the early clinical testing of iproniazid as an antituberculous agent in 1951, the development of euphoria in patients was noted among the side effects of the drug.2 In 1952, Zeller and co-workers found that iproniazid is an inhibitor of monoamine oxidase (MAO) in vivo3 and in vitro4 and suggested the potential antidepressant utility of such a compound which could result from potentiation of amines whose metabolism is normally catalyzed by this enzyme (MAO) in the central nervous system.3 This possibility was dramatized by Brodie and his associates6 and in our laboratory6 with the demonstra-(1) To whom all inquiries regarding this paper should be addressed.(2) This experience is recalled by D. M.

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