No abstract

We previously published an “Evidence Based Classification System” on Drug-Induced Acute Pancreatitis widely used by clinicians. Unfortunately, this prior analysis based only on published case reports has been misunderstood. The prior review did not include studies with higher evidentiary value, such as randomized trials, case control studies and/or pharmacoepidemiologic studies. Despite the extensive list of drugs included in our prior classification and review, which defined classes by the case reports showing rechallenges and latency, the value to clinicians and applicability to patients with unexplained acute pancreatitis is profoundly limited. The use of the prior classification system has led to many patients inappropriately labeled as having a drug-induced acute pancreatitis. We now propose a “Revised” Evidence Based Classification System for the purpose of determining which drugs cause acute pancreatitis based on the GRADE Criteria.

2 5 69%) as shown in Table . The pooled rate of total significant histopathological change was 32.9% (23.8-43.5, I 2 5 96%). Conclusion: Based on meta-analysis of 22 studies, normal colon biopsy was observed in 49.8% and normal ileum biopsy was observed in 88.5%. Pooled rate of microscopic colitis was 15.1% and total significant histopathological change was noted in 32.9%. Our study adds important data to the current clinical care of patients with chronic diarrhea who undergo colonoscopy exam with random biopsies.[0174] Figure 1. Flow diagram of search results and citation screening for Therapy-associated Polyposis citations