Δ⁹-Tetrahydrocannabinol (THC) elicited a dose-dependent (3.2–24 μM) response for form/movement, cellular growth and division in log growth phase and division-synchronized Tetrahymena pyriformis GL. Progressive dose-dependent action of THC on division delays in division-synchronized cell cultures was correlated with a concomitant reduction of division maxima and the percent of cells that completed division I. THC depressed the incorporation of 5-³H-uridine, 2-¹⁴C-thymidine and L-3-¹⁴C-phenylalanine into RNA, DNA and protein macromolecules respectively of division-synchronized Tetrahymena during division I, The depression of incorporation of 5-³H-uridine into nucleic acid macromolecules was correlated with a reduction of exogeneous precursor in the cellular pool. The specific activity of radiolabeled mRNA and nascent polypeptides of polyribosomal fractions from synchronized cells was reduced by THC treatment. THC caused an inhibition of the incorporation of 5-³H-uridine into ribosomal RNA (17S and 25S RNA) and ribosomal precursor RNA (35S RNA) of synchronized cells.

The findings suggest that nursing professionals could recommend that women with ovarian cancer exercise 225 minutes per week regardless of cancer and/or treatment trajectory. For those experiencing aches and pains, behavioral supports and suggestions of a lower exercise dose are needed to maintain physical activity.

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Study supported by Merck Investigator Studies Program Grant * Only Grade 1-2 toxicities occurring in >10% patients are depicted Possibly or probably related to study drug