In patients with chronic constipation, treatment with lubiprostone produces a BM in the majority of individuals within 24-48 h of initial dosing and improves the frequency as well as other characteristics associated with BMs with short-term (i.e., 4 wk) treatment. The most commonly reported adverse event was mild to moderate nausea, which resulted in treatment discontinuation in 5% of treated patients.

No abstract

In phase reconstruction MR imaging, e.g., for velocity measurement, phase shifts beyond +/- pi radians will "wrap around" to smaller apparent phases. Such large phase shifts could arise either due to large background (non-flow-related) phase variations or due to large velocity-induced phase shifts. For sufficiently smooth phase variation, such discontinuities can be automatically recognized and corrected, thus restoring the correct phase values and extending the effective dynamic range of such phase imaging techniques.

No abstract