The aim of the research was to study the relationship between the level of vaspin and the thickness of the intima-media of the carotid artery (CIMT), parameters of carbohydrate and lipid metabolism, functional state of the pancreas, markers of inflammation, and to create a mathematical model for the progression of atherosclerosis in patients with type 2 diabetes mellitus (DM-2) and chronic pancreatitis (CP). Materials and methods: Serum vaspin level in 114 people with DM-2 or CP and a combination of these diseases were obtained. The parameters of lipid and carbohydrate metabolism, inflammation and functional status of pancreas were studied. CIMT was measured by means of B-mode ultrasonography. The obtained data were processed by the methods of non-parametric statistics to study the dependence of the parameters on the group, questions of the statistical significance of differences between two unrelated groups, the tightness of the relationship between the analyzed parameters. Results: A statistically significant (p<0.05) increase in serum vaspin levels in patients with DM-2 compared with other studied groups was obtained. A reliable correlation between vaspin, carbohydrate metabolism and CIMT was obtained, and it appeared to be dependent on the presence of comorbid pathology. The value of vaspin / tumor necrosis factor-α (TNF-α), starting from which CIMT increase is considered present, was calculated. Conclusions: Undertaken study confirmed the positive connection of vaspin with insulin resistance markers, but also demonstrated that serum vaspin levels is positively associated with CIMT. A mathematical model for predicting the progression of atherosclerosis in patients with the studied pathology was developed. It was demonstrated that the Vaspin/TNF-α ratio can be used as a marker of early atherosclerotic lesion of vascular wall, indicating the role of vaspin in atherogenesis

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Objective: To evaluate the effect of chronic pancreatitis (CP) and exocrine insufficiency of the pancreas on the carotid intima media thickness (cIMT) in patients with type 2 diabetes mellitus (DM-2). Materials and methods: 91 patients were examined, they were divided into groups: 1st group-patients with DM-2 (n = 31) group 2nd – DM-2 combined with CP (n = 60). Fasting plasma glucose (FPG), HbA1c, immunoreactive insulin (IRI), HOMA-IR index, C-reactive protein (CRP), serum α-amylase and fecal-1 elastase (FE-1) were assessed. In order to assess the thickness of the cIMT, ultrasound of the common carotid artery was performed. The control group of healthy volunteers was representative by age and sex. Results: In the 1st and 2nd groups, the average value of cIMT was (1.02 ± 0.1 vs 1.21 ± 0.15) mm. Parameters of DM-2 management in the 1st and 2nd groups were (FPG 8.18 ± 0.92vs8.57 ± 1.2) mmol / l; HbA1c (7.23 ± 0.21vs7.49 ± 0.36)%; IRI (20.31 ± 0.9vs22.53 ± 1.2) μIU / ml; HOMA-IR (6.55 ± 1.5vs8.38 ± 2.2) μIU / ml * mmol / l; PSA (1.3 ± 0.12vs6.77 ± 0.31). HOMA-IR correlated with: CRP (r = 0.43, p <0.05 in group 1; r = 0.61, p <0.05 in group 2); FE-1 (r = -0.55, p <0.05 of the 2nd group); and cIMT (r = 0.42, p <0.05 in the 1st group; r = 0.53, p <0.05 in the 2nd group). IRI have relationship with: FE-1 (r = 0.41, p <0.05 in group 1; r = -0.3, p <0.05 in group 2); CRP (r = 0.42, p <0.05 in group 1; r = -0.28, p <0.05 in group 2); HbA1c had close relationships with cIMT (r = 0.38, p <0.05 in group 1; r = 0.51, p <0.05 in group 2). The relationship between cIMT and CRP was related in the 2nd group (r = 0.39, p <0.05); with α-amylase (r = 0.2, p <0.01 2nd group). There was no significant relationship between cIMT and FE-1 in the study. Conclusions: Obtained data allows us to conclude that hyperinsulinemia and insulin resistance have a direct atherogenic effect on the walls of blood vessels. It is established that the accession of the inflammatory process leads to increasing development of atherosclerotic lesions of the vessel, at the same time, the presence of exocrine dysfunction of the pancreas does not have a significant direct effect on the cIMT.

To analyze the data of the scientific literature on the importance of vaspin as a pathogenetic link in the development of insufficiency of exocrine function of the pancreas in type 2 diabetes patients in combination with chronic pancreatitis and. Literary sources were searched in the scientometric databases Scopus and Web of Science, using the electronic search system Pubmed, mainly for the last 5 years. The search terms were: “type 2 diabetes”, “chronic pancreatitis”, “pancreas”, “exocrine function of the pancreas”, “obesity”, “vaspin”, “type 2 diabetes mellitus”, “pancreas », « obesity »,« vaspin ». An increase in the incidence of chronic pancreatitis and type 2 diabetes mellitus, as well as its severe complications, which are often associated with insulin resistance, hyperinsulinemia. Comorbid conditions can contribute to dysfunction of the pancreas. The existing relationships between vaspin level, insulin resistance, type 2 diabetes mellitus and chronic pancreatitis are not well understood. Many authors see the value and information content of vaspin as a biomarker for diagnosing these diseases and predicting treatment outcomes. The study of the effects and mechanisms of action of vaspin is the basis for determining new targets for the treatment of diabetes mellitus and chronic pancreatitis, both in isolated pathology and in combination.

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